The PPG is committed to a tightly integrated, cross-disciplinary design, bringing multiple levels of analysis and techniques to bear on shared specific themes in linking social phenotype to brain to gene. An overarching goal for the PPG is to create a framework to link each Project with the others. Core B is at the heart of this function, ensuring that, to the extent possible, participants are investigated by each of the disciplines represented by the different Projects. Core B, based at The Salk Institute's Laboratory for Cognitive Neuroscience (LCN), with Dr. Ursula Bellugi serving as Principal Investigator, is an efficient model for achieving this goal through its provision of a central infrastructure for the following services: (i)Planning and executing outreach activities that establish and maintain connections with the target participant communities (WS, DD) through referral sources as well as local, national, and international organizations;(ii)ldentifying and recruiting potential participants;(iii) Performing the induction screening, administering and scoring the Core Diagnostic Battery, and gathering medical and background information necessary for the application of inclusionary/exclusionary criteria;(iv) Administering and scoring a Core Cognitive Battery;(v) Coordinating an efficient schedule of participation across Projects;(vi) Tracking and ensuring the participation of all subjects across Projects;(vii) Coordinating the acquisition, transport, and collection of human tissue samples (e.g., blood samples for Project I;dental pulp for Project 11;brain tissue for Project 111). Overall, Core B centralizes the participant recruitment efforts and oversees participant tracking and participation inappropriate Projects.
; One of the NICHD missions is research that leads to increased understanding and treatment of social behavior and emotional disorders. Relatively little research has targeted the study of genes to neural circuits to social behavior, uniti our PPG studies. Bore B is instrumental in laying out the foundation (by recruiting subjects and centralizing the data collected by all projects) for such an interdisciplinary program.
|Herai, Roberto R; Stefanacci, Lisa; Hrvoj-Mihic, Branka et al. (2014) Micro RNA detection in long-term fixed tissue of cortical glutamatergic pyramidal neurons after targeted laser-capture neuroanatomical microdissection. J Neurosci Methods 235:76-82|
|Hoeft, Fumiko; Dai, Li; Haas, Brian W et al. (2014) Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. PLoS One 9:e104088|
|Freitas, Beatriz C G; Trujillo, Cleber A; Carromeu, Cassiano et al. (2014) Stem cells and modeling of autism spectrum disorders. Exp Neurol 260:33-43|
|Hanson, Kari L; Hrvoj-Mihic, Branka; Semendeferi, Katerina (2014) A dual comparative approach: integrating lines of evidence from human evolutionary neuroanatomy and neurodevelopmental disorders. Brain Behav Evol 84:135-55|
|Ng, Rowena; Järvinen, Anna; Bellugi, Ursula (2014) Toward a deeper characterization of the social phenotype of Williams syndrome: The association between personality and social drive. Res Dev Disabil 35:1838-49|
|Ng, Rowena; Lai, Philip; Levitin, Daniel J et al. (2013) Musicality Correlates With Sociability and Emotionality in Williams Syndrome. J Ment Health Res Intellect Disabil 6:268-279|
|Mills, D L; Dai, L; Fishman, I et al. (2013) Genetic mapping of brain plasticity across development in Williams syndrome: ERP markers of face and language processing. Dev Neuropsychol 38:613-42|
|Teffer, Kate; Semendeferi, Katerina (2012) Human prefrontal cortex: evolution, development, and pathology. Prog Brain Res 195:191-218|
|Fishman, Inna; Ng, Rowena; Bellugi, Ursula (2012) Neural processing of race by individuals with Williams syndrome: do they show the other-race effect? (And why it matters). Soc Neurosci 7:373-84|
|Haas, B W; Hoeft, F; Barnea-Goraly, N et al. (2012) Preliminary evidence of abnormal white matter related to the fusiform gyrus in Williams syndrome: a diffusion tensor imaging tractography study. Genes Brain Behav 11:62-8|
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