The PPG is committed to a tightly integrated, cross-disciplinary design, bringing multiple levels of analysis and techniques to bear on shared specific themes in linking social phenotype to brain to gene. An overarching goal for the PPG is to create a framework to link each Project with the others. Core B is at the heart of this function, ensuring that, to the extent possible, participants are investigated by each of the disciplines represented by the different Projects. Core B, based at The Salk Institute's Laboratory for Cognitive Neuroscience (LCN), with Dr. Ursula Bellugi serving as Principal Investigator, is an efficient model for achieving this goal through its provision of a central infrastructure for the following services: (i)Planning and executing outreach activities that establish and maintain connections with the target participant communities (WS, DD) through referral sources as well as local, national, and international organizations;(ii)ldentifying and recruiting potential participants;(iii) Performing the induction screening, administering and scoring the Core Diagnostic Battery, and gathering medical and background information necessary for the application of inclusionary/exclusionary criteria;(iv) Administering and scoring a Core Cognitive Battery;(v) Coordinating an efficient schedule of participation across Projects;(vi) Tracking and ensuring the participation of all subjects across Projects;(vii) Coordinating the acquisition, transport, and collection of human tissue samples (e.g., blood samples for Project I;dental pulp for Project 11;brain tissue for Project 111). Overall, Core B centralizes the participant recruitment efforts and oversees participant tracking and participation inappropriate Projects.
; One of the NICHD missions is research that leads to increased understanding and treatment of social behavior and emotional disorders. Relatively little research has targeted the study of genes to neural circuits to social behavior, uniti our PPG studies. Bore B is instrumental in laying out the foundation (by recruiting subjects and centralizing the data collected by all projects) for such an interdisciplinary program.
|Griesi-Oliveira, Karina; Suzuki, Angela May; Muotri, Alysson Renato (2017) TRPC Channels and Mental Disorders. Adv Exp Med Biol 976:137-148|
|Herai, Roberto H; Negraes, Priscilla D; Muotri, Alysson R (2017) Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA. Hum Mol Genet 26:2472-2479|
|Ng, Rowena; Brown, Timothy T; Järvinen, Anna M et al. (2016) Structural integrity of the limbic-prefrontal connection: Neuropathological correlates of anxiety in Williams syndrome. Soc Neurosci 11:187-92|
|Ng, Rowena; Brown, Timothy T; Erhart, Matthew et al. (2016) Morphological differences in the mirror neuron system in Williams syndrome. Soc Neurosci 11:277-88|
|Green, Tamar; Fierro, Kyle C; Raman, Mira M et al. (2016) Surface-based morphometry reveals distinct cortical thickness and surface area profiles in Williams syndrome. Am J Med Genet B Neuropsychiatr Genet 171B:402-13|
|Järvinen, Anna; Ng, Rowena; Crivelli, Davide et al. (2015) Relations between social-perceptual ability in multi- and unisensory contexts, autonomic reactivity, and social functioning in individuals with Williams syndrome. Neuropsychologia 73:127-40|
|Järvinen, Anna; Ng, Rowena; Bellugi, Ursula (2015) Autonomic response to approachability characteristics, approach behavior, and social functioning in Williams syndrome. Neuropsychologia 78:159-70|
|Ng, Rowena; Fishman, Inna; Bellugi, Ursula (2015) Frontal asymmetry index in Williams syndrome: Evidence for altered emotional brain circuitry? Soc Neurosci 10:366-75|
|Marinkovic, Ksenija; Courtney, Maureen G; Witzel, Thomas et al. (2014) Spatio-temporal dynamics and laterality effects of face inversion, feature presence and configuration, and face outline. Front Hum Neurosci 8:868|
|Freitas, Beatriz C G; Trujillo, Cleber A; Carromeu, Cassiano et al. (2014) Stem cells and modeling of autism spectrum disorders. Exp Neurol 260:33-43|
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