Core C the histopathology core has been an invaluable cost effective asset to the work of the PPG since its inception. It has provided a wide variety of histological services to PPG investigators including improvements that maintain the state of the art status of the core. The histology services provided by the Core include tissue processing, paraffin embedding, sectioning, staining and immunohistochemistry. Core personnel have also assisted investigators in the collection of animal tissues for histologic studies. New services have come on-line as they have become commercially available. The Core has a laser capture microscope for tissue microdissection that was recently upgraded to support immunofluorescence detection. This has been used on Project III. The Core has also purchased a tissue microarrayer. In addition, the Core provides digital photomicrographs of selected histologic findings to program investigators. In past years, the Core's histology services have been used to a varying extent by all of the investigators - except for the old Project I in nonhuman primates which took advantage of the core in only a minor way because primate center has its own histology/pathology lab. For the upcoming PPG all three of the projects will use the core services. Dr. Thomas oversees the program and offers personal advice and assistance as needed. Ms. Gendron is an outstanding histologist who works day to day with members of the PPG team. She is highly effective. She is especially adept at getting immunohistology techniques to work. Members of the PPG are allowed to have their tissues processed at no additional charge to their individual projects. This is financially possible because of our partnership with the OHSU Knight Cancer Institute.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD034430-17
Application #
8675874
Study Section
Special Emphasis Panel (ZHD1-DSR-Z)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
17
Fiscal Year
2014
Total Cost
$93,091
Indirect Cost
$32,642
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Jonker, S S; Louey, S (2016) Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment. J Endocrinol 228:R1-18
Chadderdon, Scott M; Belcik, J Todd; Bader, Lindsay et al. (2016) Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance. Diabetes 65:2249-57
Barry, James S; Rozance, Paul J; Brown, Laura D et al. (2016) Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood) 241:839-47
Kolahi, Kevin; Louey, Samantha; Varlamov, Oleg et al. (2016) Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells. PLoS One 11:e0153522
Hashima, Jason N; Rogers, Vanessa; Langley, Stephen M et al. (2015) Fetal ventricular interactions and wall mechanics during ductus arteriosus occlusion in a sheep model. Ultrasound Med Biol 41:1020-8
Jonker, Sonnet S; Louey, Samantha; Giraud, George D et al. (2015) Timing of cardiomyocyte growth, maturation, and attrition in perinatal sheep. FASEB J 29:4346-57
Thornburg, K L (2015) The programming of cardiovascular disease. J Dev Orig Health Dis 6:366-76
Thornburg, Kent L; Marshall, Nicole (2015) The placenta is the center of the chronic disease universe. Am J Obstet Gynecol 213:S14-20
Boone-Heinonen, Janne; Messer, Lynne C; Fortmann, Stephen P et al. (2015) From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity. Prev Med 81:451-9
Jonker, Sonnet S; Giraud, George D; Espinoza, Herbert M et al. (2015) Effects of chronic hypoxia on cardiac function measured by pressure-volume catheter in fetal chickens. Am J Physiol Regul Integr Comp Physiol 308:R680-9

Showing the most recent 10 out of 91 publications