There are two main parts of this program project. The first part consists of a longitudinal, multidisciplinary study of 200 preschool aged children (75 with autism, 50 with mental retardation, and 75 with typical development). Projects I-IV are each a component of this longitudinal study, focusing on one of the following domains of early development: Project I: social cognition and patterns of functional electrophysiological brain imaging in response to social stimuli; Project II: Precursors of speech and language, and patterns of functional electrophysiological brain imaging to speech stimuli; Project III: Developmental course during early infancy, including variations in age of symptom onset; Project IV: Brain structure and metabolism, as assessed by magnetic resonance imaging and spectroscopy. Individual differences in each domain will be related to concurrent measures of neuropsychological functioning and will be used to predict response to intervention and outcome in autism at 6-7 years of age. The second major part of the program project is a collaborative genetic linkage study of sibling pairs with autism (Project V). Information gained in the longitudinal study (Projects I-IV) will be used to empirically-validate neurobiological subtypes of autism, and this information will be subsequently used to model genetic heterogeneity. Thus, all five research projects iwll function as a whole in an integrated, synergistic way to offer a deeper understanding of the neurobiological and genetic basis of autism. Core A will provide administrative support, and be responsible for diagnostic and neuropsychological evaluations. Core B will provide statistical and technical support to the projects.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD035465-03
Application #
6017160
Study Section
Special Emphasis Panel (ZHD1-MRG-C (04))
Program Officer
Hanson, James W
Project Start
1997-06-01
Project End
2002-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Charman, Tony; Young, Gregory S; Brian, Jessica et al. (2017) Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Res 10:169-178
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Vieland, Veronica J; Hallmayer, Joachim; Huang, Yungui et al. (2011) Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. J Neurodev Disord 3:113-23
Pinto, Dalila; Pagnamenta, Alistair T; Klei, Lambertus et al. (2010) Functional impact of global rare copy number variation in autism spectrum disorders. Nature 466:368-72
Kim, Jieun E; Lyoo, In Kyoon; Estes, Annette M et al. (2010) Laterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder. Arch Gen Psychiatry 67:1187-97

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