The Assessment Core has three major goals. The first is to ascertain approximately 150 new participants for the studies being conducted by all of the Subprojects within this next phase of our Program Project. The ascertainment process will include coordinating human participant reviews at the New York State Institute or Basic Research in Developmental Disabilities (IBR), as well as obtaining informed consent for new participants. We will also obtain new informed consents for the approximately 150 participants from our previous studies that will be continuing enrollment in our program, and an additional group of 20 - 30 younger adults with Down syndrome who will be studied in Subproject 3. The second major goal of the Core is to coordinate and conduct comprehensive assessments of our 300 study participants in close collaboration with investigators within Subprojects 1, 2, 3 and 4. Our third goal, in close collaboration with Subproject 1, 2, 3, 4 and the Genetics Core, will be to collect blood samples from program participants for analyses of biomarkers, genotype and epigenetic studies of methylation. The fourth goal will be to enter data from assessments into our Core database to facilitate analyses by Program Subprojects, and to maintain a separate participant tracking database. These activities will ensure that all Program participants are characterized using standardized procedures and common measures, providing rich descriptions of phenotype, facilitating analyses within individual Subprojects, and supporting interactions among Subprojects.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD035897-24
Application #
8376135
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
24
Fiscal Year
2012
Total Cost
$519,417
Indirect Cost
$11,547
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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Esbensen, Anna J; Mailick, Marsha R; Silverman, Wayne (2013) Long-term impact of parental well-being on adult outcomes and dementia status in individuals with Down syndrome. Am J Intellect Dev Disabil 118:294-309
Janicki, S C; Park, N; Cheng, R et al. (2013) Aromatase variants modify risk for Alzheimer's disease in a multiethnic female cohort. Dement Geriatr Cogn Disord 35:340-6
Xing, Luzhou; Salas, Martha; Zhang, Hong et al. (2013) Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Mamm Genome 24:30-43

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