This application proposes the establishment of a Program Project at Baylor College of Medicine to study male infertility with a focus on investigation the etiology of abnormal sperm production and the application of assisted reproductive techniques to overcome these defects. The Program Project will have as its nucleus a core administrative unit that will coordinate the activities of the basic and clinical scientists on a day to day basis. The focus of this Program Project will be in the area of the molecular biology of male infertility with specific emphasis on defining the genes required for normal spermatogenesis. Assisted reproductive techniques have been used to overcome many male factor defects. It is assumed that if a sperm can fertilize, than it is """"""""healthy"""""""". We have no scientific basis for this belief and many of these offspring could be carrying genetic defects.
The aims for the proposal are: 1. To establish a program project for the study of male infertility creating a close working relationship between basic and clinical scientists from the Departments of Urology, Obstetrics and Gynecology., Cell Biology, and Medical Genetics. Bring these groups together in one project will create a more effective focus on male infertility than would occur with these scientists working individually. 2. To Create a facility to analyze DNA and perform in situ hybridization represents a significant a significant and critical component of this Program Project. 3. To correlate clinical features of male infertility with new discoveries at the mo level, to better understand the diseases processes and thereby to develop ad more effective treatment and diagnostic modalities. The expertise of this multi-disciplinary group of scientists working together is expected to yield new understanding of the basic pathophysiology of male infertility.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
1P01HD036289-01A2
Application #
6027954
Study Section
Special Emphasis Panel (ZHD1-PRG-G (DL))
Program Officer
Taymans, Susan
Project Start
2000-05-10
Project End
2005-04-30
Budget Start
2000-05-10
Budget End
2001-04-30
Support Year
1
Fiscal Year
2000
Total Cost
$703,014
Indirect Cost
Name
Baylor College of Medicine
Department
Urology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Carrell, D T; Nyboe Andersen, A; Lamb, D J (2015) The need to improve patient care through discriminate use of intracytoplasmic sperm injection (ICSI) and improved understanding of spermatozoa, oocyte and embryo biology. Andrology 3:143-6
Garcia, Jose M; Chen, Ji-an; Guillory, Bobby et al. (2015) Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice. Biol Reprod 93:24
Gomez, Lissette; Kovac, Jason R; Lamb, Dolores J (2015) CYP17A1 inhibitors in castration-resistant prostate cancer. Steroids 95:80-7
Eisenberg, Michael L; Li, Shufeng; Betts, Paul et al. (2015) Testosterone therapy and cancer risk. BJU Int 115:317-21
Jorgez, Carolina J; Wilken, Nathan; Addai, Josephine B et al. (2015) Genomic and genetic variation in E2F transcription factor-1 in men with nonobstructive azoospermia. Fertil Steril 103:44-52.e1
Eisenberg, M L; Li, S; Herder, D et al. (2015) Testosterone therapy and mortality risk. Int J Impot Res 27:46-8
Eisenberg, Michael L; Li, Shufeng; Behr, Barry et al. (2014) Semen quality, infertility and mortality in the USA. Hum Reprod 29:1567-74
Kovac, Jason R; Rajanahally, Saneal; Smith, Ryan P et al. (2014) Patient satisfaction with testosterone replacement therapies: the reasons behind the choices. J Sex Med 11:553-62
Kovac, Jason R; Pan, Michael M; Lipshultz, Larry I et al. (2014) Current state of practice regarding testosterone supplementation therapy in men with prostate cancer. Steroids 89:27-32
Kovac, Jason R; Kovac, Jason; Pastuszak, Alexander W et al. (2014) Testosterone supplementation therapy in the treatment of patients with metabolic syndrome. Postgrad Med 126:149-56

Showing the most recent 10 out of 72 publications