Abstract

This core is the central element of our P01 application. It is responsible for generating, identifying, and preserving the mouse infertility models that will be used by the three Projects, and which will be made available to the research community. The cornerstone of the Core is to generate large numbers of mutant mice and conduct a genome-wide screen for mutations causing sterility in mice. The second major component is phenotyping of infertility mutants, and to classify them for possible subsequent analysis by one of the three Projects. Mutations will be validated genetically, and then either expanded for further detailed studies by one or more of the Projects, or cryopreserved and offered to the community at large through personal contacts and the Program Project Website. Below, the specific roles of the core are outlined in more detail.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD042137-10
Application #
8380506
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$161,239
Indirect Cost
$51,029

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Hays, E; Majchrzak, N; Daniel, V et al. (2017) Spermatogenesis associated 22 is required for DNA repair and synapsis of homologous chromosomes in mouse germ cells. Andrology 5:299-312
Fujiwara, Yasuhiro; Matsumoto, Hirokazu; Akiyama, Kouyou et al. (2015) An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility. Reproduction 149:67-74
Sun, Fengyun; Fujiwara, Yasuhiro; Reinholdt, Laura G et al. (2015) Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis. Chromosoma 124:397-415
Pattabiraman, Shrivatsav; Baumann, Claudia; Guisado, Daniela et al. (2015) Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability. J Cell Biol 208:53-69
Harris, Tanya P; Schimenti, Kerry J; Munroe, Robert J et al. (2014) IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. G3 (Bethesda) 4:367-72
Li, Xin Zhiguo; Roy, Christian K; Dong, Xianjun et al. (2013) An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell 50:67-81
Liu, Ye; Zaun, Hans C; Orlowski, John et al. (2013) CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis. J Neurosci 33:12656-69
Fujiwara, Yasuhiro; Ogonuki, Narumi; Inoue, Kimiko et al. (2013) t-SNARE Syntaxin2 (STX2) is implicated in intracellular transport of sulfoglycolipids during meiotic prophase in mouse spermatogenesis. Biol Reprod 88:141
Schimenti, Kerry J; Feuer, Sky K; Griffin, Laurie B et al. (2013) AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics 194:447-57
Gómez, Rocío; Jordan, Philip W; Viera, Alberto et al. (2013) Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis suggests functions in distinct chromosome processes. J Cell Sci 126:4239-52

Showing the most recent 10 out of 32 publications