The objective of the Sheep Core is to provide a mechanism whereby the services of common personnel are shared by all projects of this Program Project Grant, enabling cost-effective breeding and animal maintenance programs of exceptionally high standards. The underlying rationale for this Core is simple. A staff of well-qualified individuals can meet the needs of multiple research projects more effectively and economically than if each project were to meet its needs separately. This is especially important given that a major function of this core will be to generate sheep that have been programmed prenatally by exposure to gonadal steroids at known stages of pregnancy. This requires extensive experience and expertise of managing fertility, breeding, and early postnatal care in this experimental species.
The Specific Aims of the Sheep Core are as follows.
Specific Aim 1. To operate a breeding program to generate sheep those are prenatally treated with gonadal steroids at specific fetal ages and vehicle-treated controls for use by the three research projects that make up this Program Project Grant.
Specific Aim 2. To coordinate effective and economical usage of sheep by three interrelated research projects.
Specific Aim 3. To provide a uniform and high standard of animal maintenance and veterinary care.
Specific Aim 4. To provide a technical knowledge base for reproductive research in sheep and train personnel in proper handling of animals.
Specific Aim 5. To determine the metabolic status of the experimental animals required for meeting the needs of all 3 projects. By achieving these aims, the Sheep Core will greatly enhance the productivity of all projects in the Program Project Grant.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-L)
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University of Michigan Ann Arbor
Ann Arbor
United States
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Beckett, E M; Astapova, O; Steckler, T L et al. (2014) Developmental programing: impact of testosterone on placental differentiation. Reproduction 148:199-209
Veiga-Lopez, A; Wurst, A K; Steckler, T L et al. (2014) Developmental programming: postnatal estradiol amplifies ovarian follicular defects induced by fetal exposure to excess testosterone and dihydrotestosterone in sheep. Reprod Sci 21:444-55
Padmanabhan, V; Veiga-Lopez, A (2014) Reproduction Symposium: developmental programming of reproductive and metabolic health. J Anim Sci 92:3199-210
Delaney, Angela; Padmanabhan, Vasantha; Rezvani, Geoffrey et al. (2014) Evolutionary conservation and modulation of a juvenile growth-regulating genetic program. J Mol Endocrinol 52:269-77
Sliwowska, Joanna H; Fergani, Chrysanthi; Gawa?ek, Monika et al. (2014) Insulin: its role in the central control of reproduction. Physiol Behav 133:197-206
Padmanabhan, Vasantha; Salvetti, Natalia R; Matiller, Valentina et al. (2014) Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep. Endocrinology 155:3649-60
Jackson, Leslie M; Mytinger, Andrea; Roberts, Eila K et al. (2013) Developmental programming: postnatal steroids complete prenatal steroid actions to differentially organize the GnRH surge mechanism and reproductive behavior in female sheep. Endocrinology 154:1612-23
Padmanabhan, Vasantha; Veiga-Lopez, Almudena (2013) Animal models of the polycystic ovary syndrome phenotype. Steroids 78:734-40
Veiga-Lopez, A; Moeller, J; Patel, D et al. (2013) Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep. Endocrinology 154:1731-42
Veiga-Lopez, Almudena; Ye, Wen; Padmanabhan, Vasantha (2012) Developmental programming: prenatal testosterone excess disrupts anti-Mullerian hormone expression in preantral and antral follicles. Fertil Steril 97:748-56

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