The primary objective of the Administrative Core is to provide overall administrative support to the program. This administrative support will include communication with the institutional administration, maintaining and distribufing records regarding the fiscal management of the grant, preparing annual program reports, and coordinating the meetings of the advisory committees. In addition, the Administrative Core will maintain records of such things as IRB approvals, Institutional Animal Care and Use Committee approvals, and signed consent forms. Finally, the Core will provide data management and statistical support for all of the projects. These activities will be under the direction of Dr. James C. Rose and he will be advised at the monthly meetings of the project investigators concerning all aspects of progress on the project and administrative issues. The administrative team is made up of senior investigators and an administrative secretary with extensive experience in coordinating and managing the activities of multidisciplinary groups. Ms. Melissa Whitson will assist Dr. Rose in these activities and Dr. Beverly Snively will oversee the data analysis activities. The following specific objectives are proposed: 1) To promote efficient use of the PPG's resources;2) to promote the exchange of scientific ideas and data within not only the P01 Working Group, made up of the Project Leaders, the Directors of the Cores, and the Co-investigators participating in this PPG, but also with the larger scientific community;3) to provide internal and external review of the progress made by the PPG and, 4) to provide experimental design and data analysis support for the project.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD047584-09
Application #
8712520
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
9
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
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South, Andrew M; Nixon, Patricia A; Chappell, Mark C et al. (2018) Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity. J Hypertens 36:2092-2101
Chappell, Mark C; Al Zayadneh, Ebaa M (2017) Angiotensin-(1-7) and the Regulation of Anti-Fibrotic Signaling Pathways. J Cell Signal 2:
Washburn, Lisa K; Nixon, Patricia A; Snively, Beverly M et al. (2017) Antenatal corticosteroids and cardiometabolic outcomes in adolescents born with very low birth weight. Pediatr Res 82:697-703
Massmann, G Angela; Zhang, Jie; Seong, Won Joon et al. (2017) Sex-dependent effects of antenatal glucocorticoids on insulin sensitivity in adult sheep: role of the adipose tissue renin angiotensin system. Am J Physiol Regul Integr Comp Physiol 312:R1029-R1038
Sigmund, Curt D; Diz, Debra I; Chappell, Mark C (2017) No Brain Renin-Angiotensin System: Déjà vu All Over Again? Hypertension 69:1007-1010
South, Andrew M; Nixon, Patricia A; Chappell, Mark C et al. (2017) Antenatal corticosteroids and the renin-angiotensin-aldosterone system in adolescents born preterm. Pediatr Res 81:88-93
Su, Yixin; Bi, Jianli; Pulgar, Victor M et al. (2017) Antenatal betamethasone attenuates the angiotensin-(1-7)-Mas receptor-nitric oxide axis in isolated proximal tubule cells. Am J Physiol Renal Physiol 312:F1056-F1062
Wilson, Bryan A; Chappell, Mark C (2017) Assessment of the Renin-Angiotensin System in Cellular Organelle: New Arenas for Study in the Mitochondria. Methods Mol Biol 1614:99-121
Nixon, Patricia A; Washburn, Lisa K; Michael O'Shea, Thomas et al. (2017) Antenatal steroid exposure and heart rate variability in adolescents born with very low birth weight. Pediatr Res 81:57-62

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