The primary objective of the Administrative Core is to provide overall administrative support to the program. This administrative support will include communication with the institutional administration, maintaining and distribufing records regarding the fiscal management of the grant, preparing annual program reports, and coordinating the meetings of the advisory committees. In addition, the Administrative Core will maintain records of such things as IRB approvals, Institutional Animal Care and Use Committee approvals, and signed consent forms. Finally, the Core will provide data management and statistical support for all of the projects. These activities will be under the direction of Dr. James C. Rose and he will be advised at the monthly meetings of the project investigators concerning all aspects of progress on the project and administrative issues. The administrative team is made up of senior investigators and an administrative secretary with extensive experience in coordinating and managing the activities of multidisciplinary groups. Ms. Melissa Whitson will assist Dr. Rose in these activities and Dr. Beverly Snively will oversee the data analysis activities. The following specific objectives are proposed: 1) To promote efficient use of the PPG's resources;2) to promote the exchange of scientific ideas and data within not only the P01 Working Group, made up of the Project Leaders, the Directors of the Cores, and the Co-investigators participating in this PPG, but also with the larger scientific community;3) to provide internal and external review of the progress made by the PPG and, 4) to provide experimental design and data analysis support for the project.

National Institute of Health (NIH)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1)
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Wake Forest University Health Sciences
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Washburn, Lisa K; Brosnihan, K Bridget; Chappell, Mark C et al. (2015) The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst 16:529-38
Marshall, Allyson C; Shaltout, Hossam A; Pirro, Nancy T et al. (2014) Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides 52:74-81
Wilson, Bryan A; Marshall, Allyson C; Alzayadneh, Ebaa M et al. (2014) The ins and outs of angiotensin processing within the kidney. Am J Physiol Regul Integr Comp Physiol 307:R487-9
Chappell, Mark C; Marshall, Allyson C; Alzayadneh, Ebaa M et al. (2014) Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne) 4:201
Lee, J-H; Zhang, J; Massmann, G A et al. (2014) Antenatal betamethasone increases vascular reactivity to endothelin-1 by upregulation of CD38/cADPR signaling. J Dev Orig Health Dis 5:56-62
Marshall, Allyson C; Pirro, Nancy T; Rose, James C et al. (2014) Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem 130:313-23
Bi, Jianli; Contag, Stephen A; Chen, Kai et al. (2014) Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep. Am J Physiol Renal Physiol 307:F1013-22
Nixon, P A; Washburn, L K; O'Shea, T M (2013) Antenatal steroid exposure and pulmonary outcomes in adolescents born with very low birth weight. J Perinatol 33:806-10
Washburn, Lisa; Nixon, Patricia; Russell, Gregory et al. (2013) Adiposity in adolescent offspring born prematurely to mothers with preeclampsia. J Pediatr 162:912-7.e1
Marshall, Allyson C; Shaltout, Hossam A; Pirro, Nancy T et al. (2013) Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am J Physiol Regul Integr Comp Physiol 305:R679-88

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