Outline of Core Activities I. Provide a sophisticated laboratory assay service dedicated to the particular needs of our investigators, namely, the requirement of small individual sample sizes and significant constraints on total blood volume per experiment available for analysis II. Manage analyses of genomic and epigenetic responses in leukocytes a. Link investigators to existing centers (e.g.. Center for Epigenetics and Metabolism under the leadership of Core B Co-Investigator Dr. Paolo Sassone-Corsi) b. Utilize resources at UCI in Biomedical Informatics and Biostatistics to ensure state-of-the-art analysis of genomic and epigenetic data III. Perform state-of-the-art measurements of leukocyte function including flow cytometry, cell culture, and cytokine production IV. Maintain databases of all stored human and rat blood, tissue, and fluids

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD048721-07
Application #
8404039
Study Section
Pediatrics Subcommittee (CHHD)
Project Start
Project End
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
7
Fiscal Year
2013
Total Cost
$474,327
Indirect Cost
$165,775
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Ganesan, Goutham; Leu, Szu-Yun; Cerussi, Albert et al. (2016) Cerebral and Muscle Tissue Oxygenation During Incremental Cycling in Male Adolescents Measured by Time-Resolved Near-Infrared Spectroscopy. Pediatr Exerc Sci 28:275-85
Tran, Brian D; Chiu, Abraham; Tran, Charlene et al. (2016) Exercise and Repeated Testing Improves Accuracy of Laser Doppler Assessment of Microvascular Function Following Shortened (1-minute) Blood Flow Occlusion. Microcirculation 23:293-300
Lu, Kim D; Billimek, John; Bar-Yoseph, Ronen et al. (2016) Sex Differences in the Relationship between Fitness and Obesity on Risk for Asthma in Adolescents. J Pediatr 176:36-42
Falk, B; Haddad, F; Klentrou, P et al. (2016) Differential sclerostin and parathyroid hormone response to exercise in boys and men. Osteoporos Int 27:1245-9
Lakes, Kimberley D; Marvin, Shesha; Rowley, Jessica et al. (2016) Dancer perceptions of the cognitive, social, emotional, and physical benefits of modern styles of partnered dancing. Complement Ther Med 26:117-22
Horvath, Peter; Oliver, Stacy R; Zaldivar, Frank P et al. (2015) Effects of intravenous glucose and lipids on innate immune cell activation in healthy, obese, and type 2 diabetic subjects. Physiol Rep 3:
Shin, Hye-Won; Barletta, Barbara; Yoonessi, Leila et al. (2015) Quantification of Aerosol Hydrofluoroalkane HFA-134a Elimination in the Exhaled Human Breath Following Inhaled Corticosteroids Administration. Clin Transl Sci 8:445-50
Ganesan, Goutham; Cotter, Joshua A; Reuland, Warren et al. (2015) Effect of blood flow restriction on tissue oxygenation during knee extension. Med Sci Sports Exerc 47:185-93
Ashish, Naveen; Bamman, Marcas M; Cerny, Frank J et al. (2015) The clinical translation gap in child health exercise research: a call for disruptive innovation. Clin Transl Sci 8:67-76
Liem, Robert I; Onyejekwe, Kasiemobi; Olszewski, Marie et al. (2015) The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia. Br J Haematol 171:854-61

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