Abstract

The Administrative Core is designed to facilitate successful development of the Program Project by fostering interactions among individual investigators. The administrative responsibilities will include the planning and overall administration of the Program Project. This Program Project utilizes the expertise of investigators at Yale University School of Medicine, and builds on their diverse interests and expertise in Reproductive Immunology. The overall goal of the Core is to foster the research proposed and the development of ongoing objectives as well as effective interactions among the research projects and the supporting Core Facilities. This will include integration of activities between the research projects to ensure that key objectives are obtained to define the role of TLRs in the regulation of the immune system during pregnancy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD054713-04
Application #
8378432
Study Section
Special Emphasis Panel (ZHD1-MCHG-B)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$150,181
Indirect Cost
$83,433

  Institution

Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Kwon, Ja-Young; Aldo, Paulomi; You, Yuan et al. (2018) Relevance of placental type I interferon beta regulation for pregnancy success. Cell Mol Immunol 15:1010-1026
Racicot, Karen; Kwon, Ja Young; Aldo, Paulomi et al. (2016) Type I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection-Induced Preterm Birth. Am J Reprod Immunol 75:451-60
Mhatre, Mohak V; Potter, Julie A; Lockwood, Charles J et al. (2016) Thrombin Augments LPS-Induced Human Endometrial Endothelial Cell Inflammation via PAR1 Activation. Am J Reprod Immunol 76:29-37
Silasi, Michelle; Cardenas, Ingrid; Kwon, Ja-Young et al. (2015) Viral infections during pregnancy. Am J Reprod Immunol 73:199-213
Norwitz, Errol R; Bonney, Elizabeth A; Snegovskikh, Victoria V et al. (2015) Molecular Regulation of Parturition: The Role of the Decidual Clock. Cold Spring Harb Perspect Med 5:
Mor, Gil; Kwon, Ja-Young (2015) Trophoblast-microbiome interaction: a new paradigm on immune regulation. Am J Obstet Gynecol 213:S131-7
Young, Omar M; Tang, Zhonghua; Niven-Fairchild, Tracy et al. (2015) Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. Am J Reprod Immunol 73:22-35
Racicot, Karen E; Wünsche, Vera; Auerbach, Ben et al. (2014) Human chorionic gonadotropin enhances trophoblast-epithelial interaction in an in vitro model of human implantation. Reprod Sci 21:1274-80
Hoang, Mai; Potter, Julie A; Gysler, Stefan M et al. (2014) Human fetal membranes generate distinct cytokine profiles in response to bacterial Toll-like receptor and nod-like receptor agonists. Biol Reprod 90:39
Dekel, Nava; Gnainsky, Yulia; Granot, Irit et al. (2014) The role of inflammation for a successful implantation. Am J Reprod Immunol 72:141-7

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