The Administrative Core is designed to facilitate successful development of the Program Project by fostering interactions among individual investigators. The administrative responsibilities will include the planning and overall administration of the Program Project. This Program Project utilizes the expertise of investigators at Yale University School of Medicine, and builds on their diverse interests and expertise in Reproductive Immunology. The overall goal of the Core is to foster the research proposed and the development of ongoing objectives as well as effective interactions among the research projects and the supporting Core Facilities. This will include integration of activities between the research projects to ensure that key objectives are obtained to define the role of TLRs in the regulation of the immune system during pregnancy.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD054713-04
Application #
8378432
Study Section
Special Emphasis Panel (ZHD1-MCHG-B)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$150,181
Indirect Cost
$83,433
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Racicot, Karen; Kwon, Ja Young; Aldo, Paulomi et al. (2016) Type I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection-Induced Preterm Birth. Am J Reprod Immunol 75:451-60
Mhatre, Mohak V; Potter, Julie A; Lockwood, Charles J et al. (2016) Thrombin Augments LPS-Induced Human Endometrial Endothelial Cell Inflammation via PAR1 Activation. Am J Reprod Immunol 76:29-37
Silasi, Michelle; Cardenas, Ingrid; Kwon, Ja-Young et al. (2015) Viral infections during pregnancy. Am J Reprod Immunol 73:199-213
Young, Omar M; Tang, Zhonghua; Niven-Fairchild, Tracy et al. (2015) Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. Am J Reprod Immunol 73:22-35
Norwitz, Errol R; Bonney, Elizabeth A; Snegovskikh, Victoria V et al. (2015) Molecular Regulation of Parturition: The Role of the Decidual Clock. Cold Spring Harb Perspect Med 5:
Mor, Gil; Kwon, Ja-Young (2015) Trophoblast-microbiome interaction: a new paradigm on immune regulation. Am J Obstet Gynecol 213:S131-7
Dekel, Nava; Gnainsky, Yulia; Granot, Irit et al. (2014) The role of inflammation for a successful implantation. Am J Reprod Immunol 72:141-7
Racicot, Karen; Kwon, Ja-Young; Aldo, Paulomi et al. (2014) Understanding the complexity of the immune system during pregnancy. Am J Reprod Immunol 72:107-16
Aldo, Paulomi B; Racicot, Karen; Craviero, Vinicius et al. (2014) Trophoblast induces monocyte differentiation into CD14+/CD16+ macrophages. Am J Reprod Immunol 72:270-84
Kwon, Ja-Young; Romero, Roberto; Mor, Gil (2014) New insights into the relationship between viral infection and pregnancy complications. Am J Reprod Immunol 71:387-90

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