The overall purpose of the Administrative Core is to provide scientific leadership, organizational management including regulatory oversight, administrative, fiscal and human resource services, and communications with key stakeholders forthis multi-project program through a solid, seamless foundation. This core is critical to the successful implementation of all three individual projects. It is also critical for the overall success of the program project by supporting linkages between the projects and cores under one umbrella. These linkages maximize scientific output, create efficiencies in operations, and ensure harmonious communications with constituencies. The administrative core will be co-led by Drs. Havlir (UCSF) and Kamya (Makerere University;IDRC). An experienced administrative team will ensure that the complex operational components ofthe program, including fiscal and regulatory aspects, run smoothly and objectives are met. The specific objectives of the core are: Objective 1: To provide scientific leadership to ensure each project achieves its scientific goals. This includes the Scientific Steering Committee (SSC) which will oversee the progress of each of the projects in the program;an external Scientific Advisory Board (SAB) composed of four outside experts;and the Tororo Community Advisory Board to evaluate project objectives and safety.The Admin Core will organize a monthly call to discuss and track progress on manuscript and publications from the PROMOTE program. Objective 2: To provide organizational management of all aspects of the program, including fiscal, human and resource management, and regulatory oversight. Objective 3: To support internal linkages within the project and external linkages with key stakeholders. Stakeholders include the Ministry of Health (MoH), The AIDS Support Organization (TASO), Infectious Diseases Research Collaboration (IDRC), and Makerere University in Uganda, and University of California, San Francisco (UCSF), the University of Georgia (UGA), the Federal Drug Authority (FDA), National Institute of Child Health and Development (NICHD) in the US.

Public Health Relevance

The Administrative Core provides the foundation forthe integration and organization of the POI program. The overall purpose of the Administrative Core is to provide scientific leadership, organizational and financial management, administrative services, regulatory oversight and communications with key stakeholders.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01HD059454-07
Application #
8706922
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Jagannathan, Prasanna; Nankya, Felistas; Stoyanov, Cristina et al. (2015) IFN? Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection. J Infect Dis 211:1987-96
Kakuru, Abel; Achan, Jane; Muhindo, Mary K et al. (2014) Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Clin Infect Dis 59:446-53
Bartelink, Imke H; Savic, Rada M; Mwesigwa, Julia et al. (2014) Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV-infected pregnant and breastfeeding women in Tororo, Uganda. J Clin Pharmacol 54:121-32
Koss, Catherine A; Natureeba, Paul; Plenty, Albert et al. (2014) Risk factors for preterm birth among HIV-infected pregnant Ugandan women randomized to lopinavir/ritonavir- or efavirenz-based antiretroviral therapy. J Acquir Immune Defic Syndr 67:128-35
Conrad, Melissa D; Bigira, Victor; Kapisi, James et al. (2014) Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children. PLoS One 9:e105690
Young, Sera L; Plenty, Albert H J; Luwedde, Flavia A et al. (2014) Household food insecurity, maternal nutritional status, and infant feeding practices among HIV-infected Ugandan women receiving combination antiretroviral therapy. Matern Child Health J 18:2044-53
Kamya, Moses R; Kapisi, James; Bigira, Victor et al. (2014) Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS 28:2701-9
Bigira, Victor; Kapisi, James; Clark, Tamara D et al. (2014) Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. PLoS Med 11:e1001689
Ruel, Theodore D; Kakuru, Abel; Ikilezi, Gloria et al. (2014) Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy. J Acquir Immune Defic Syndr 65:535-41
Ikilezi, Gloria; Achan, Jane; Kakuru, Abel et al. (2013) Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies. Am J Trop Med Hyg 88:744-6

Showing the most recent 10 out of 15 publications