The discovery of mirror neurons (MNs) in the monkey has been one of the most important advances of our knowledge about the role of the motor system in action perception. More impor-tantly, this discovery has attracted the attention of scientists from many disciplines because of its possible implications in explaining important aspects of primate social cognition such as the under-standing of others'goals and acfions (Jeannerod 1994;Rizzolatti et al. 2001). More recent neurophysiological and neuroimaging studies are giving significant impulse to our understanding of the mirror neuron system (MNS) and are raising questions concerning their specific functions. Some researchers have argued that this system is precociously funcfioning since infancy in both humans and monkeys (Lepage &Theoret 2006;Ferrari et al. 2006) and prob-ably serving very basic functions in early social interactions. These functions might constitute im-portant precursors of higher order socio-cognitive skills fully expressed in adulthood. Among them, particularly relevant is the capacity to understand others'intentions since it can impact individual's decisions in determining the course of social interactions. A lack of such social comprehension might compromise basic social faculties necessary for everyday life. The primary objective of the project is to understand the developmental trajectory characte-rizing the early functioning of the MNs in monkeys with respect to later development of high order socio-cognitive skills and, secondly, to elucidate the involvement of MNs in such skills. The project consists of two interrelated parts.
The specific aim of the first part is to track longitudinally the relation between early behavioral markers of MN and the development of sociocognitive skills.
The specific aim of the second part is to investigate how MN integrate information about the social con-text with that of the observed agent's action. This neural mechanism enables the monkey to under-stand the intention of the observed agent which is crucial to make appropriate decisions and to determine future social interactions.

Public Health Relevance

Mirror Neurons (MNs) are cortical neurons that activate during both action execution and action observation thus constituting a system matching action perception with internal motor representations. The capacity of MNs to use a common code for action and perception has important implications for cognitive neuroscience research as it provides new insights on the neurobiological mechanisms underlying the capacity to understand and to imitate others'behavior.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD064653-03
Application #
8382491
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$197,387
Indirect Cost
$35,896
Name
University of Maryland College Park
Department
Type
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Yoo, Kathryn H; Cannon, Erin N; Thorpe, Samuel G et al. (2016) Desynchronization in EEG during perception of means-end actions and relations with infants' grasping skill. Br J Dev Psychol 34:24-37
Dettmer, Amanda M; Kaburu, Stefano S K; Byers, Kristen L et al. (2016) First-time rhesus monkey mothers, and mothers of sons, preferentially engage in face-to-face interactions with their infants. Am J Primatol 78:238-46
Tramacere, Antonella; Pievani, Telmo; Ferrari, Pier F (2016) Mirror neurons in the tree of life: mosaic evolution, plasticity and exaptation of sensorimotor matching responses. Biol Rev Camb Philos Soc :
Simpson, Elizabeth A; Nicolini, Ylenia; Shetler, Melissa et al. (2016) Experience-independent sex differences in newborn macaques: Females are more social than males. Sci Rep 6:19669
Simpson, Elizabeth A; Miller, Grace M; Ferrari, Pier F et al. (2016) Neonatal imitation and early social experience predict gaze following abilities in infant monkeys. Sci Rep 6:20233
Fox, Nathan A; Bakermans-Kranenburg, Marian J; Yoo, Kathryn H et al. (2016) Assessing human mirror activity with EEG mu rhythm: A meta-analysis. Psychol Bull 142:291-313
Kaburu, Stefano S K; Paukner, Annika; Simpson, Elizabeth A et al. (2016) Neonatal imitation predicts infant rhesus macaque (Macaca mulatta) social and anxiety-related behaviours at one year. Sci Rep 6:34997
Jakobsen, Krisztina V; Umstead, Lindsey; Simpson, Elizabeth A (2016) Efficient human face detection in infancy. Dev Psychobiol 58:129-36
Cannon, Erin N; Simpson, Elizabeth A; Fox, Nathan A et al. (2016) Relations between infants' emerging reach-grasp competence and event-related desynchronization in EEG. Dev Sci 19:50-62
Coudé, Gino; Festante, Fabrizia; Cilia, Adriana et al. (2016) Mirror Neurons of Ventral Premotor Cortex Are Modulated by Social Cues Provided by Others' Gaze. J Neurosci 36:3145-56

Showing the most recent 10 out of 71 publications