The broad, long-term goal of this project is to develop, validate and study a large-scale dynamic neural network model of the human brain areas comprising the human mirror neuron system (MNS). This system is thought to enable an individual's understanding of the meaning of acfions performed by others, and the potential imitation and learning of those actions, and recent studies implicate dysfunction of the MNS system in autism. However, little is known about the development and the plasficity of the MNS in infants and children, how these infants come to understand and acquire their first actions, and the degree of plasticity of the system in adults. To address these gaps, this project will use large-scale computer model simulations of the MNS to deepen our understanding of the basic neurobiological mechanisms and computafional algorithms that underlie the development and plasticity of the MNS. By closely interacting with the Companion Projects, the model will integrate human and non-human primate data from various modalities including single cell recordings, scalp electroencephalogram (EEG), and behavior, and use these data to validate the model at various stages of development. Moreover, by using simulated developmental abnormalities reported in the literature, in a systematic fashion, we will assess the adequacy of the model to account for behavioral and EEG data reported in autism, and to increase our understanding of the funcfions and roles of the MNS in three fundamental abilities central to adaptive human functioning: 1) the ability to deploy actions strategically in service of goals, 2) the ability to infer the goals or acfions of one's social partners, and 3) the ability to learn via imitation. In summary, this research proposes a series of experiments integrating behavioral, electrophysiological, and mathematical modeling methods to investigate the basic neurobiological mechanisms that underlie the emergence of the MNS in infants and its plasticity in adults.

Public Health Relevance

Recent research implicates the human mirror neuron system (MNS) in parallel systems for social communication (e.g., language, theory of mind and empathy) and action production (e.g., tool use, imitation), and in explaining autism. Thus, this research will lead to new knowledge needed to devise novel training/intervention programs to reduce the burden of developmental disorders of cognition and acfion.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD064653-03
Application #
8382493
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$183,960
Indirect Cost
$35,896
Name
University of Maryland College Park
Department
Type
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Tramacere, Antonella; Pievani, Telmo; Ferrari, Pier F (2017) Mirror neurons in the tree of life: mosaic evolution, plasticity and exaptation of sensorimotor matching responses. Biol Rev Camb Philos Soc 92:1819-1841
Simpson, Elizabeth A; Jakobsen, Krisztina V; Damon, Fabrice et al. (2017) Face Detection and the Development of Own-Species Bias in Infant Macaques. Child Dev 88:103-113
Filippi, Courtney A; Cannon, Erin N; Fox, Nathan A et al. (2016) Motor System Activation Predicts Goal Imitation in 7-Month-Old Infants. Psychol Sci 27:675-84
Simpson, Elizabeth A; Suomi, Stephen J; Paukner, Annika (2016) Evolutionary relevance and experience contribute to face discrimination in infant macaques (Macaca mulatta). J Cogn Dev 17:285-299
Kaburu, Stefano S K; Paukner, Annika; Simpson, Elizabeth A et al. (2016) Neonatal imitation predicts infant rhesus macaque (Macaca mulatta) social and anxiety-related behaviours at one year. Sci Rep 6:34997
Coudé, Gino; Festante, Fabrizia; Cilia, Adriana et al. (2016) Mirror Neurons of Ventral Premotor Cortex Are Modulated by Social Cues Provided by Others' Gaze. J Neurosci 36:3145-56
Bowman, Lindsay C; Thorpe, Samuel G; Cannon, Erin N et al. (2016) Action mechanisms for social cognition: behavioral and neural correlates of developing Theory of Mind. Dev Sci :
Yoo, Kathryn H; Cannon, Erin N; Thorpe, Samuel G et al. (2016) Desynchronization in EEG during perception of means-end actions and relations with infants' grasping skill. Br J Dev Psychol 34:24-37
Filippi, Courtney A; Woodward, Amanda L (2016) Action Experience Changes Attention to Kinematic Cues. Front Psychol 7:19
Cannon, Erin N; Simpson, Elizabeth A; Fox, Nathan A et al. (2016) Relations between infants' emerging reach-grasp competence and event-related desynchronization in EEG. Dev Sci 19:50-62

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