The discovery of mirror neurons (MNs) in the monkey has been one of the most important advances of our knowledge about the role of the motor system in action perception. More impor-tantly, this discovery has attracted the attention of scientists from many disciplines because of its possible implications in explaining important aspects of primate social cognition such as the under-standing of others'goals and acfions (Jeannerod 1994;Rizzolatti et al. 2001). More recent neurophysiological and neuroimaging studies are giving significant impulse to our understanding of the mirror neuron system (MNS) and are raising questions concerning their specific functions. Some researchers have argued that this system is precociously funcfioning since infancy in both humans and monkeys (Lepage &Theoret 2006;Ferrari et al. 2006) and prob-ably serving very basic functions in early social interactions. These functions might constitute im-portant precursors of higher order socio-cognitive skills fully expressed in adulthood. Among them, particularly relevant is the capacity to understand others'intentions since it can impact individual's decisions in determining the course of social interactions. A lack of such social comprehension might compromise basic social faculties necessary for everyday life. The primary objective of the project is to understand the developmental trajectory characte-rizing the early functioning of the MNs in monkeys with respect to later development of high order socio-cognitive skills and, secondly, to elucidate the involvement of MNs in such skills. The project consists of two interrelated parts.
The specific aim of the first part is to track longitudinally the relation between early behavioral markers of MN and the development of sociocognitive skills.
The specific aim of the second part is to investigate how MN integrate information about the social con-text with that of the observed agent's action. This neural mechanism enables the monkey to under-stand the intention of the observed agent which is crucial to make appropriate decisions and to determine future social interactions.

Public Health Relevance

Mirror Neurons (MNs) are cortical neurons that activate during both action execution and action observation thus constituting a system matching action perception with internal motor representations. The capacity of MNs to use a common code for action and perception has important implications for cognitive neuroscience research as it provides new insights on the neurobiological mechanisms underlying the capacity to understand and to imitate others'behavior.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD064653-04
Application #
8473237
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$191,228
Indirect Cost
$35,414
Name
University of Maryland College Park
Department
Type
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Krogh-Jespersen, Sheila; Kaldy, Zsuzsa; Valadez, Annalisa Groth et al. (2018) Goal prediction in 2-year-old children with and without autism spectrum disorder: An eye-tracking study. Autism Res 11:870-882
Simpson, Elizabeth A; Paukner, Annika; Pedersen, Eric J et al. (2018) Visual preferences for direct-gaze faces in infant macaques (Macaca mulatta) with limited face exposure. Dev Psychobiol :
Krogh-Jespersen, Sheila; Woodward, Amanda L (2018) Reaching the goal: Active experience facilitates 8-month-old infants' prospective analysis of goal-based actions. J Exp Child Psychol 171:31-45
Salo, Virginia C; Ferrari, Pier F; Fox, Nathan A (2018) The role of the motor system in action understanding and communication: Evidence from human infants and non-human primates. Dev Psychobiol :
Festante, Fabrizia; Vanderwert, Ross E; Sclafani, Valentina et al. (2018) EEG beta desynchronization during hand goal-directed action observation in newborn monkeys and its relation to the emergence of hand motor skills. Dev Cogn Neurosci 30:142-149
Novack, Miriam A; Filippi, Courtney A; Goldin-Meadow, Susan et al. (2018) Actions speak louder than gestures when you are 2 years old. Dev Psychol 54:1809-1821
Bowers, M E; Buzzell, G A; Bernat, E M et al. (2018) Time-frequency approaches to investigating changes in feedback processing during childhood and adolescence. Psychophysiology 55:e13208
Damon, Fabrice; Méary, David; Quinn, Paul C et al. (2017) Preference for facial averageness: Evidence for a common mechanism in human and macaque infants. Sci Rep 7:46303
Simpson, Elizabeth A; Paukner, Annika; Sclafani, Valentina et al. (2017) Acute oxytocin improves memory and gaze following in male but not female nursery-reared infant macaques. Psychopharmacology (Berl) 234:497-506
Baker, Maggie; Lindell, Stephen G; Driscoll, Carlos A et al. (2017) Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques. Proc Natl Acad Sci U S A 114:11769-11774

Showing the most recent 10 out of 87 publications