Two fundamental abilities are central to adaptive human functioning and human development: the ability to deploy actions strategically in service of goals and the ability to apprehend the goals of social partners in order to produce appropriate social responses. Recent neuroscientific findings indicate that these foundational capacities are intimately related: A neural network known as the mirror neuron system (MNS) responds both when we perform an action and when we observe someone else perform that action. These findings hold the potential to revolutionize scientific understanding of the ontogeny of goal-directed action and social-cognitive functioning. However, progress in realizing this potential has been held back by the lack of neural measures of MNS activity in infants, a lack of integrated measures of social-cognitive functions in infants, and the need to develop models of MNS dynamics during development. The Program Project proposed here addresses these needs: Project I will develop EEG methods for assessing MNS activity in human infants, children, and adults as well as infant and adult monkeys. These methods will provide a unified methodological core for the remaining projects. Projects II &III will investigate the social-cognitive functions of the MNS in human infants and infant and adult monkeys, integrating measures of social cognitive functioning with the neural measures developed in Project 1. Project IV will develop a neurocomputational model of the developing MNS, integrating data across all projects. Administrative Core A will provide budgetary and logistical support for each project, provide participant recruitment (Project I, II, IV), and support integrative and outreach activities. EEG/Computational Core B will provide facilities and expertise to support the deployment of the methods developed in Project I across the other projects. This large-scale collaboration emerges from ongoing collaborative work across these laboratories that has laid the groundwork and developed initial methods for taking the program to the next level. The products of this work will provide critical new insights into the development of foundational human capacities as well as innovative new tools, approaches and insights for broader developmental, comparative, and clinical research.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-H (WA))
Program Officer
Freund, Lisa S
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University of Maryland College Park
Schools of Arts and Sciences
College Park
United States
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Yoo, Kathryn H; Cannon, Erin N; Thorpe, Samuel G et al. (2016) Desynchronization in EEG during perception of means-end actions and relations with infants' grasping skill. Br J Dev Psychol 34:24-37
Dettmer, Amanda M; Kaburu, Stefano S K; Byers, Kristen L et al. (2016) First-time rhesus monkey mothers, and mothers of sons, preferentially engage in face-to-face interactions with their infants. Am J Primatol 78:238-46
Tramacere, Antonella; Pievani, Telmo; Ferrari, Pier F (2016) Mirror neurons in the tree of life: mosaic evolution, plasticity and exaptation of sensorimotor matching responses. Biol Rev Camb Philos Soc :
Simpson, Elizabeth A; Nicolini, Ylenia; Shetler, Melissa et al. (2016) Experience-independent sex differences in newborn macaques: Females are more social than males. Sci Rep 6:19669
Simpson, Elizabeth A; Miller, Grace M; Ferrari, Pier F et al. (2016) Neonatal imitation and early social experience predict gaze following abilities in infant monkeys. Sci Rep 6:20233
Fox, Nathan A; Bakermans-Kranenburg, Marian J; Yoo, Kathryn H et al. (2016) Assessing human mirror activity with EEG mu rhythm: A meta-analysis. Psychol Bull 142:291-313
Kaburu, Stefano S K; Paukner, Annika; Simpson, Elizabeth A et al. (2016) Neonatal imitation predicts infant rhesus macaque (Macaca mulatta) social and anxiety-related behaviours at one year. Sci Rep 6:34997
Jakobsen, Krisztina V; Umstead, Lindsey; Simpson, Elizabeth A (2016) Efficient human face detection in infancy. Dev Psychobiol 58:129-36
Cannon, Erin N; Simpson, Elizabeth A; Fox, Nathan A et al. (2016) Relations between infants' emerging reach-grasp competence and event-related desynchronization in EEG. Dev Sci 19:50-62
Coudé, Gino; Festante, Fabrizia; Cilia, Adriana et al. (2016) Mirror Neurons of Ventral Premotor Cortex Are Modulated by Social Cues Provided by Others' Gaze. J Neurosci 36:3145-56

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