Core A, Administrative Core will provide scientific leadership for and facilitate communication among the 3 Projects and 2 other Cores of the proposed Program Project.
Aim 1. Scientific Leadership. Administrative Core A will be led by Kirk P. Conrad MD (also PD of the Program Project & PI of Project 1) who conceived of the proposed PPG targeting ART and assembled the requisite experts as Project and Core leaders to study this highly understudied patient population. Since January 2008, the group has met on a regular basis in person, by teleconference and WebEx. Dr. Conrad is responsible for the overall planning and coordination of program activities at the University of Florida and Stanford University. In addition, he will facilitate all communications and interactions among the Projects and Cores. R. Stan Williams MD (Co-l Project 1) will provide up to date information on subject recruitment, as well as subject obstetrical and perinatal outcomes for the UF-based CTSI study. Mark S. Segal MD, PhD (PI of Project II) will provide updates on subject flow, retention and clinical research activities in the CTSI. Charles E. Wood PhD (Co-l on Project 1 and Analytical Core B) will assist Dr. Conrad and other Administrative Core A members in general problem solving.
Aim 2. Communication. To establish efficient communication and interaction among Project and Core components. This Core will organize the monthly joint Executive Committee/Administrative Core A Meeting (facilitated by teleconference and WebEx for Valerie L. Baker PI Project 111 and personnel), as well as the annual combined Internal and External Advisory Committee Meeting for which external advisory committee members and Dr. Baker will come to Florida. There will also be bimonthly meetings among all Projects and Core members (again facilitated by IT for non-UF personnel) in which we will review the latest literature, share ideas and preliminary results, troubleshoot and chart future directions. Core A will also interface with NICHD RSB.
Aim 3. Administrative. To provide administrative assistance to Pis. Core A will track publications of PPG members, assure proper acknowledgement of funding support, and coordinate the preparation of the annual Progress Report to the NIH.
Aim 4. Budget. A major duty is to oversee the Program Project budget.

Public Health Relevance

Although the Administrative Core A is relatively small, it is critical for providing scientific leadership and facilitating communication among the component PPG Projects and Cores. Core A is thus essential for the success of the proposed Program Project.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-Z)
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University of Florida
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Zhang, Xinrui; Muller, Keith E; Goodenow, Maureen M et al. (2018) Internal pilot design for balanced repeated measures. Stat Med 37:375-389
Ogunleye, Oluseyi; Campo, Bertha; Herrera, Diana et al. (2017) Relaxin confers cytotrophoblast protection from hypoxia-reoxygenation injury through the phosphatidylinositol 3-kinase-Akt/protein kinase B cell survival pathway. Am J Physiol Regul Integr Comp Physiol 312:R559-R568
Conrad, Kirk P; Rabaglino, Maria Belen; Post Uiterweer, Emiel D (2017) Emerging role for dysregulated decidualization in the genesis of preeclampsia. Placenta 60:119-129
Floyd, Erin G; von Versen-Höynck, Frauke; Liu, Jing et al. (2016) Collection of pregnancy outcome records following infertility-challenges and possible solutions. J Assist Reprod Genet 33:993-9
Baker, Valerie L; Brown, Morton B; Luke, Barbara et al. (2015) Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650,000 assisted reproductive technology cycles. Fertil Steril 104:1145-52.e1-5
Lathi, Ruth B; Chi, Yueh-Yun; Liu, Jing et al. (2015) Frozen blastocyst embryo transfer using a supplemented natural cycle protocol has a similar live birth rate compared to a programmed cycle protocol. J Assist Reprod Genet 32:1057-62
Baker, Valerie L; Brown, Morton B; Luke, Barbara et al. (2015) Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization. Fertil Steril 103:931-938.e2
Rabaglino, Maria B; Post Uiterweer, Emiel D; Jeyabalan, Arun et al. (2015) Bioinformatics approach reveals evidence for impaired endometrial maturation before and during early pregnancy in women who developed preeclampsia. Hypertension 65:421-9
Simpson, Sean L; Edwards, Lloyd J; Styner, Martin A et al. (2014) Separability tests for high-dimensional, low sample size multivariate repeated measures data. J Appl Stat 41:2450-2461
Conrad, Kirk P; Davison, John M (2014) The renal circulation in normal pregnancy and preeclampsia: is there a place for relaxin? Am J Physiol Renal Physiol 306:F1121-35

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