ADMINISTRATIVE CORE A The Administrative Core A will provide leadership for the Craniosynostosis Network and be responsible for coordinating the three Projects, two Cores, 12 collaborating subcontracts, and two consultants. Organizational issues will include setting general policies for the overall Network and investigators, including compliance with human subjects, animal care policies, and data sharing regulations. The Core also will be responsible for organizing meetings for its investigators, trainees, and staff and budgetary issues. All de-identified information and samples obtained from subcontracts will be organized through this Core. These items will be coded, entered into a database, and redistributed to Molecular/Analytic Core B and Projects. Assisting the Core will be an Advisory Committee of scientists with expertise to evaluate the Network once a year. An Executive Committee of multiple Principal Investigators from each Project and Core will be established and meet at least monthly to review progress and discuss issues related to the research plan, personnel and budget of the Network. The Executive Committee will be responsible for progress reports, presentations, and publications. Monthly research meetings will be organized to discuss progress and in conjunction with these meetings, an open seminar will be held. The Executive Committee will attend the annual NICHD Structural Birth Defects Working Group meeting which is held in the Washington, DC/Rockville, MD area.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD078233-05
Application #
9657560
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2019-02-01
Budget End
2020-01-31
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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Holmes, Greg; Zhang, Lening; Rivera, Joshua et al. (2018) C-type natriuretic peptide analog treatment of craniosynostosis in a Crouzon syndrome mouse model. PLoS One 13:e0201492
Martínez-Abadías, Neus; Mateu Estivill, Roger; Sastre Tomas, Jaume et al. (2018) Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis. Elife 7:
Musy, Marco; Flaherty, Kevin; Raspopovic, Jelena et al. (2018) A quantitative method for staging mouse embryos based on limb morphometry. Development 145:
Holmes, Greg; O'Rourke, Courtney; Motch Perrine, Susan M et al. (2018) Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects. Development 145:
Lesciotto, Kate M; Heuzé, Yann; Jabs, Ethylin Wang et al. (2018) Choanal Atresia and Craniosynostosis: Development and Disease. Plast Reconstr Surg 141:156-168
Motch Perrine, Susan M; Stecko, Tim; Neuberger, Thomas et al. (2017) Integration of Brain and Skull in Prenatal Mouse Models of Apert and Crouzon Syndromes. Front Hum Neurosci 11:369
Wilkie, Andrew O M; Johnson, David; Wall, Steven A (2017) Clinical genetics of craniosynostosis. Curr Opin Pediatr 29:622-628
Starbuck, John M; Cole 3rd, Theodore M; Reeves, Roger H et al. (2017) The Influence of trisomy 21 on facial form and variability. Am J Med Genet A 173:2861-2872
Lee, Chanyoung; Richtsmeier, Joan T; Kraft, Reuben H (2017) A COMPUTATIONAL ANALYSIS OF BONE FORMATION IN THE CRANIAL VAULT USING A COUPLED REACTION-DIFFUSION-STRAIN MODEL. J Mech Med Biol 17:

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