The Administrative Core will be the central office for the administration of the Program Project. It will be coordinated through the Department of Pathology. The Principal Investigator, Dr. Darrel Stafford and the Administrator, Cynthia Taylor will meet regularly to go over items of interest pertaining to fiscal matters of all projects. The internal advisors will be contacted on a regular basis to keep members up to date on the research accomplishments. The external advisors will be invited to visit as needed to meet with the principal investigators of each sub project for comments and critique of research progress. These advisors will be charged with altering the scientific direction of each sub project should the need arise. The Administrative Core will insure smooth integration between the individual projects and will oversee weekly meetings of the investigators in room 442 of Wilson Hall. The Administrative Core will also coordinate the visits of the External Advisory committee and will be responsible for organizing the scientific program to be presented to the Advisory Committees. The Administrative Core will also organize all meetings of the Principal Investigators of the sub projects and will be responsible for the preparation of manuscripts, abstracts, human and animal rights protocols, monthly financial reports, and annual progress reports relating to the program project. Travel to scientific meetings by the members of the program project will be organized by the Administrative Core although travel requests will be in each individual sub project. The accounting mechanism for this program project will be carried through the Administrative Core as overseen by Ms. Cynthia Taylor, Administrator and with the direction of Dr. Darrel Stafford. All expenditures will be monitored by Ms. Taylor. The Administrative Core will also be responsible for communications with the NHLBI of the NIH, and the Office of Sponsored Research of the University of NC at Chapel Hill.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Bode, Michael; Mackman, Nigel (2014) Regulation of tissue factor gene expression in monocytes and endothelial cells: Thromboxane A2 as a new player. Vascul Pharmacol 62:57-62
Parker, Christine H; Morgan, Christopher R; Rand, Kasper D et al. (2014) A conformational investigation of propeptide binding to the integral membrane protein ?-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry. Biochemistry 53:1511-20
Feng, D; Stafford, K A; Broze, G J et al. (2013) Evidence of clinically significant extravascular stores of factor IX. J Thromb Haemost 11:2176-8
Owens 3rd, A Phillip; Mackman, Nigel (2012) Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque. Thromb Res 129 Suppl 2:S30-3
Owens 3rd, A Phillip; Passam, Freda H; Antoniak, Silvio et al. (2012) Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest 122:558-68
Wu, Sangwook; Liu, Shubin; Davis, Charles H et al. (2011) A hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle. J Theor Biol 279:143-9
Owens 3rd, A Phillip; Mackman, Nigel (2011) Microparticles in hemostasis and thrombosis. Circ Res 108:1284-97
Monroe, Dougald M; Mackman, Nigel; Hoffman, Maureane (2010) Wound healing in hemophilia B mice and low tissue factor mice. Thromb Res 125 Suppl 1:S74-7
Mackman, Nigel; Becker, Richard C (2010) DVT: a new era in anticoagulant therapy. Arterioscler Thromb Vasc Biol 30:369-71
de Courcy, B; Pedersen, L G; Parisel, O et al. (2010) Understanding selectivity of hard and soft metal cations within biological systems using the subvalence concept. I. Application to blood coagulation: direct cation-protein electronic effects vs. indirect interactions through water networks. J Chem Theory Comput 6:1048-1063

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