Cell membranes are fundamental to life, and defects in their function underlie many diseases. Membranes of different organelles have different lipid compositions. For example, cholesterol is markedly enriched in the plasma membrane compared with the ER. Scientists know the enzymes that synthesize and degrade the various lipids in different cell membranes. Yet, very little is known about how these enzymes are regulated so as to maintain differential lipid compositions. Our laboratory made the initial inroad into this problem through the discovery of the SREBP family of transcription factors that control synthesis and uptake of cholesterol and fatty acids. We discovered four proteins whose actions govern the regulated trafficking mechanism that dictates the activities of SREBPs. We are now in a unique position to decipher precisely how this system works at a molecular level.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Sw Medical Center Dallas
United States
Zip Code
Smagris, Eriks; BasuRay, Soumik; Li, John et al. (2015) Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. Hepatology 61:108-18
Ulrich, Victoria; Konaniah, Eddy S; Herz, Joachim et al. (2014) Genetic variants of ApoE and ApoER2 differentially modulate endothelial function. Proc Natl Acad Sci U S A 111:13493-8
Ulrich, Victoria; Konaniah, Eddy S; Lee, Wan-Ru et al. (2014) Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice. J Am Heart Assoc 3:e001369
Gusarova, Viktoria; Alexa, Corey A; Na, Erqian et al. (2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 159:691-6
Reboldi, Andrea; Dang, Eric V; McDonald, Jeffrey G et al. (2014) Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science 345:679-84
Xu, Min; Nagati, Jason S; Xie, Jian et al. (2014) An acetate switch regulates stress erythropoiesis. Nat Med 20:1018-26
Kozlitina, Julia; Smagris, Eriks; Stender, Stefan et al. (2014) Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 46:352-6
Das, Akash; Brown, Michael S; Anderson, Donald D et al. (2014) Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife 3:
Maetzel, Dorothea; Sarkar, Sovan; Wang, Haoyi et al. (2014) Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells. Stem Cell Reports 2:866-80
Lane-Donovan, Courtney; Philips, Gary T; Herz, Joachim (2014) More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron 83:771-87

Showing the most recent 10 out of 670 publications