The Molecular Biology and Lipidomics Core Laboratory is directed by Dr. Russell. He will be assisted in day-to-day operations by Dr. Jonathan Cohen, who is an expert in high-throughput DNA sequencing. This Core laboratory provides support for acrylamide gel electrophoresis of proteins, DNA sequencing, analysis of gene expression by oligonucleotide microarray hybridization and real-time polymerase chain reactions (PCRs), mass spectrometric analysis of lipids, oligonucleotide procurement, genomic DNA and RNA isolation, and the maintenance and storage of bacterial strains, plasmids, and purified proteins used within this Program Project. Two experienced technicians. Daphne Head (50% time;6 calendar months) and Jeffry Cormier (100% time;12 calendar months), and a research track faculty member (Dr. Jeffrey McDonald, 50% of time;6 calendar months) will perform the duties associated with this Core. The laboratory facility is located within the Department of Molecular Genetics.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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University of Texas Sw Medical Center Dallas
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Smagris, Eriks; BasuRay, Soumik; Li, John et al. (2015) Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. Hepatology 61:108-18
Ulrich, Victoria; Konaniah, Eddy S; Herz, Joachim et al. (2014) Genetic variants of ApoE and ApoER2 differentially modulate endothelial function. Proc Natl Acad Sci U S A 111:13493-8
Ulrich, Victoria; Konaniah, Eddy S; Lee, Wan-Ru et al. (2014) Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice. J Am Heart Assoc 3:e001369
Gusarova, Viktoria; Alexa, Corey A; Na, Erqian et al. (2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 159:691-6
Reboldi, Andrea; Dang, Eric V; McDonald, Jeffrey G et al. (2014) Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science 345:679-84
Xu, Min; Nagati, Jason S; Xie, Jian et al. (2014) An acetate switch regulates stress erythropoiesis. Nat Med 20:1018-26
Kozlitina, Julia; Smagris, Eriks; Stender, Stefan et al. (2014) Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 46:352-6
Das, Akash; Brown, Michael S; Anderson, Donald D et al. (2014) Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife 3:
Maetzel, Dorothea; Sarkar, Sovan; Wang, Haoyi et al. (2014) Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells. Stem Cell Reports 2:866-80
Lane-Donovan, Courtney; Philips, Gary T; Herz, Joachim (2014) More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron 83:771-87

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