Abstract

Core A provides administrative support for supervision and coordination of the activities of the multiple investigators associated with the Project. The Core Leader is the Program Project's Principal Investigator/Director, Dr. George Caughey, who also leads Project 1. Dr. Donald McDonald, who leads Project 3, is the Assistant Director. Dr. Caughey assumes final responsibility for the administration of the Program Project and reports to the Director of the Cardiovascular Research Institute, Dr. Shaun Coughlin. Dr. Caughey is aided by an administrative assistant and by personnel of the Cardiovascular Research Institute central offices. Core activities are based in the offices of Dr. Caughey and his assistant, and in the central offices of the Cardiovascular Research Institute.

Public Health Relevance

This Core provides administrative support for a multi-investigator, multi-disciplinary project focused on determining mechanisms of airway remodeling in chronic inflammation, which is relevant to human diseases such as bronchitis, asthma and cystic fibrosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL024136-34
Application #
8451352
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
34
Fiscal Year
2013
Total Cost
$312,645
Indirect Cost
$109,534

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Ma, Qiaoli; Dieterich, Lothar C; Ikenberg, Kristian et al. (2018) Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread. Sci Adv 4:eaat4758
Kim, Minah; Nitschké, Maximilian; Sennino, Barbara et al. (2018) Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms. Cancer Res 78:922-937
Nitschké, Maximilian; Bell, Alexander; Karaman, Sinem et al. (2017) Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. Am J Pathol 187:1984-1997
Shepherd, Joanna; Fisher, Matthew; Welford, Abigail et al. (2017) The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate. Oncotarget 8:95648-95661
Baluk, Peter; Yao, Li-Chin; Flores, Julio C et al. (2017) Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract. JCI Insight 2:
Caughey, George H (2016) Mast cell proteases as pharmacological targets. Eur J Pharmacol 778:44-55
Korhonen, Emilia A; Lampinen, Anita; Giri, Hemant et al. (2016) Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest 126:3495-510
Kim, Minah; Allen, Breanna; Korhonen, Emilia A et al. (2016) Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest 126:3511-25
Headley, Mark B; Bins, Adriaan; Nip, Alyssa et al. (2016) Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature 531:513-7
Pinkard, Henry; Stuurman, Nico; Corbin, Kaitlin et al. (2016) Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy. Nat Methods 13:807-809

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