Abstract

The CHS portion of Core A provides human lipoproteins and leukocytes and general services to the Projects and other Cores. The MRL portion of Core A provides analytical chemistry assays for the Projects and other Cores. The CHS portion of Core A has provided essential laboratory services to our Program Project since its inception. All Projects and Cores have made extensive use of this Core. A major service provided by this Core is the preparation of blood products including human monocytes, lymphocytes and occassionally platelets as well as LDL, HDL and lipoprotein deficient serum (LPDS). Over the last year alone this Core isolated 10 billion monocytes, ten grams of lipoproteins, and 38 grams of LPDS. In addition, the Core provides standard assays, centralized glassware washing, autoclaving, maintenance of common facilities and radioisotope monitoring. This Core also isolates human aortic endothelial cells and smooth muscle cells and provides these as stock cultures to the Program's Investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL030568-22
Application #
7524235
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
22
Fiscal Year
2004
Total Cost
$307,176
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Mukherjee, Pallavi; Hough, Greg; Chattopadhyay, Arnab et al. (2018) Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice. J Lipid Res 59:1818-1840
Orozco, Luz D; Farrell, Colin; Hale, Christopher et al. (2018) Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet 27:1830-1846
Erbilgin, Ayca; Seldin, Marcus M; Wu, Xiuju et al. (2018) Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol 38:2016-2027
Boström, Kristina I; Yao, Jiayi; Wu, Xiuju et al. (2018) Endothelial Cells May Have Tissue-Specific Origins. J Cell Biol Histol 1:
Norheim, Frode; Bjellaas, Thomas; Hui, Simon T et al. (2018) Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR. J Lipid Res 59:1164-1174
Yu, Jingyi; Seldin, Marcus M; Fu, Kai et al. (2018) Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res 123:73-85
Jumabay, Medet; Zhumabai, Jiayinaguli; Mansurov, Nurlan et al. (2018) Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells. J Cell Physiol 233:1812-1822
Mangul, Serghei; Yang, Harry Taegyun; Strauli, Nicolas et al. (2018) ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues. Genome Biol 19:36
Mack, Julia J; Iruela-Arispe, M Luisa (2018) NOTCH regulation of the endothelial cell phenotype. Curr Opin Hematol 25:212-218
Beceiro, Susana; Pap, Attila; Czimmerer, Zsolt et al. (2018) LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol :

Showing the most recent 10 out of 791 publications