Core C is a continuing core for Trangenic and Gene Targeting of Mice. In the next grant cycle Core C will assist Project 1 in constructing endothelial specific knockouts of SCAP and STATS on the LDL receptor null background.Core C will assist Projects 1 arid 2 in constructing HO-1 conditional and endothelial specific, knockout of HO-1 on the apoE null background. Core C will assist Project 3 in construction of a MGP-P64Q mutant mouse through gene targeting and will assist Project 3 in the generation of Abcc6-Wnt-promoterbeta- gal reporter double transgenic mice. Core C will provide consultation on breeding and colony management of transgenic mouse models to Project 4. Core C will assist Project 5 construction of, transgenci mice for testing atherosclerosis-related candidate genes. Core C will assist Project 6 with the construction of transgenic mice expressing dominant negatie NR4A receptor in macrophages. Core C will , also provide assistance to Core A in the characterization of primary cultues of mouse aortic endothelial cells by performing qPCR and Western blot analysis.These functions of Core C are essential to ensuring the efficient and cost-effective completion of the specific aims of all of the component Projects.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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University of California Los Angeles
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Yan, Xinmin; Lee, Sangderk; Gugiu, B Gabriel et al. (2014) Fatty acid epoxyisoprostane E2 stimulates an oxidative stress response in endothelial cells. Biochem Biophys Res Commun 444:69-74
Joo, Jong Wha J; Sul, Jae Hoon; Han, Buhm et al. (2014) Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies. Genome Biol 15:r61
Mangul, Serghei; Caciula, Adrian; Al Seesi, Sahar et al. (2014) Transcriptome assembly and quantification from Ion Torrent RNA-Seq data. BMC Genomics 15 Suppl 5:S7
Albright, Jody; Quizon, Pamela M; Lusis, Aldons J et al. (2014) Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery. BMC Med Genomics 7:51
Hormozdiari, Farhad; Kostem, Emrah; Kang, Eun Yong et al. (2014) Identifying causal variants at loci with multiple signals of association. Genetics 198:497-508
L├╝scher, Thomas F; Landmesser, Ulf; von Eckardstein, Arnold et al. (2014) High-density lipoprotein: vascular protective effects, dysfunction, and potential as therapeutic target. Circ Res 114:171-82
Jumabay, Medet; Abdmaulen, Raushan; Ly, Albert et al. (2014) Pluripotent stem cells derived from mouse and human white mature adipocytes. Stem Cells Transl Med 3:161-71
Ghazalpour, Anatole; Bennett, Brian J; Shih, Diana et al. (2014) Genetic regulation of mouse liver metabolite levels. Mol Syst Biol 10:730
Han, Buhm; Kang, Eun Yong; Raychaudhuri, Soumya et al. (2014) Fast pairwise IBD association testing in genome-wide association studies. Bioinformatics 30:206-13
Hasin-Brumshtein, Yehudit; Hormozdiari, Farhad; Martin, Lisa et al. (2014) Allele-specific expression and eQTL analysis in mouse adipose tissue. BMC Genomics 15:471

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