The main purpose of Core A is to provide essential administrative support for all Program Project related activities as well as to serve as the liaison between Dr. Falck (Consortium Agreement with the University of Texas) and Program Project Investigators. This Core will provide scientific, administrative, budgetary, logistic and biostatistical oversight to all components of the Program Project. The Core personnel: Dr. Schwartzman, Program Director, Core Leader;Ms. Jenks, administrator and Ms. Brown, administrative assistant will 1) facilitate communication among investigators regarding administrative and budgetary issues, allocation of funds and providing accounting updates to investigators;2) provide clerical and administrative support;3) coordinate the projects with our consultant and consortium partners;4) organize meetings among Project Leaders and External and Internal Advisory Committees and provide biostatistical support. The Core Leader is responsible for coordination, integration and administration of procedures, and will ensure compliance with institutional and federal regulatory agencies. The Core Leader will also ensure the thematic progress and the continuous interactive collaboration among investigators of this Program Project. Included in Core A is the Consortium Agreement with Dr. Falck (The University of Texas). Dr. Falck is the leading medicinal chemist in the area of cytochrome P450-derived eicosanoids. Under Dr. Falck's contractual agreement, he will continue to supply the Program Project Investigators with chemical synthesis of eicosanoid analogs and cytochrome P450 enzymatic inhibitors. The continuous development of novel analogs with greater efficacy and solubility for in vitro and in vivo studies and the supply of these compounds on a regular basis is critical for the execution and completion of the proposed studies in all three projects.

Public Health Relevance

This Core is critical to the administrative, budgetary, clerical and biostatistical aspects of this grant. This Core provides administrative logistics for coordination among Project Leaders, consultants, consortium partners and External and Internal Advisory Committees. Core A includes the consortium with Dr. Falck for the supply of eicosanoid analogs which are critical tools for all the proposed studies under this Program Project Grant.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL034300-29
Application #
8644837
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
29
Fiscal Year
2014
Total Cost
$362,519
Indirect Cost
$84,907
Name
New York Medical College
Department
Type
DUNS #
041907486
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Elijovich, Fernando; Milne, Ginger L; Brown, Nancy J et al. (2018) Two Pools of Epoxyeicosatrienoic Acids in Humans: Alterations in Salt-Sensitive Normotensive Subjects. Hypertension 71:346-355
Rocic, Petra; Schwartzman, Michal Laniado (2018) 20-HETE in the regulation of vascular and cardiac function. Pharmacol Ther 192:74-87
Singh, S P; McClung, J A; Bellner, L et al. (2018) CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1 ? Activation. Cardiovasc Pharm Open Access 7:
Schragenheim, Joseph; Bellner, Lars; Cao, Jian et al. (2018) EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter. Prostaglandins Other Lipid Mediat 137:30-39
Soler, Amanda; Hunter, Ian; Joseph, Gregory et al. (2018) Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation. J Mol Cell Cardiol 117:88-99
Wang, Lijun; Zhang, Chengbiao; Su, Xiao-Tong et al. (2017) PGF2?regulates the basolateral K channels in the distal convoluted tubule. Am J Physiol Renal Physiol 313:F254-F261
Zhang, Hui; Falck, John R; Roman, Richard J et al. (2017) Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen-Glucose Deprivation in Cortical Neurons. Cell Mol Neurobiol 37:1279-1286
Pandey, Varunkumar; Garcia, Victor; Gilani, Ankit et al. (2017) The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis. J Pharmacol Exp Ther 363:412-418
Zhang, Bin; Kandhi, Sharath; Yang, Yang-Ming et al. (2017) A novel mechanism of ascorbate direct modulation of soluble epoxide hydrolase. Prostaglandins Other Lipid Mediat 131:59-66
Garcia, Victor; Gilani, Ankit; Shkolnik, Brian et al. (2017) 20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension. Circ Res 120:1776-1788

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