This is the renewal application for PO1 HL040962, """"""""Biobehavioral Studies of Cardiovascular Disease."""""""" This Program Project studies psychobiological dimensions of individual differences and variation in socioenvironmental and nutritional exposures as potential etiological variables or markers of correlated pathogenic processes in heart disease. We propose three related research projects, supported by three Core Units. Investigators represent psychology and psychiatry, clinical pharmacology, human neuroscience, molecular genetics, cell biology, epidemiology, and statistics. Project 1 seeks to establish whether psychosocial and lifestyle-related risk factors for cardiovascular disease are associated with individual differences in the reactivity of key neural structures underlying emotional processing and appetitive motivation. Project 2 will investigate stress-related features of the social environment (in both occupational and home contexts), tracking individuals'behavioral and biological reactions in real time and elucidating pathways to preclinical vascular disease. Project 3 will address a mechanism of potential relevance to several behavioral and biological risk factors - omega-3 fatty acids - as studied by both observational and experimental methodologies. These objectives will be pursued in the context of a single, multi-component data collection that will both satisfy specific aims of the individual projects and create opportunities for synergistic exploration across methods and levels of analysis. The study sample will include 530 middle-aged adults without clinically apparent atherosclerotic disease, and study methods will encompass functional neuroimaging, ecological momentary assessment of experienced environments, ambulatory blood pressure and neuroendocrine assessments, laboratory clinical evaluations, heteromethod personality and health behavior assessments, vascular imaging, and molecular genetic analyses. These Projects are facilitated by Core Units providing centralized administrative, data management and participant accrual services;instrumentation support and development;and both general biostatistical and specialized data analytic services and consultation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL040962-20
Application #
8217288
Study Section
Special Emphasis Panel (ZHL1-PPG-L (M1))
Program Officer
Kaufmann, Peter G
Project Start
1988-07-01
Project End
2014-01-31
Budget Start
2012-02-01
Budget End
2014-01-31
Support Year
20
Fiscal Year
2012
Total Cost
$1,944,786
Indirect Cost
$711,133
Name
University of Pittsburgh
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
John-Henderson, Neha A; Marsland, Anna L; Kamarck, Thomas W et al. (2016) Childhood Socioeconomic Status and the Occurrence of Recent Negative Life Events as Predictors of Circulating and Stimulated Levels of Interleukin-6. Psychosom Med 78:91-101
Cundiff, Jenny M; Kamarck, Thomas W; Manuck, Stephen B (2016) Daily Interpersonal Experience Partially Explains the Association Between Social Rank and Physical Health. Ann Behav Med 50:854-861
Miller, Karissa G; Wright, Aidan G C; Peterson, Laurel M et al. (2016) Trait positive and negative emotionality differentially associate with diurnal cortisol activity. Psychoneuroendocrinology 68:177-85
John-Henderson, Neha A; Kamarck, Thomas W; Muldoon, Matthew F et al. (2016) Early Life Family Conflict, Social Interactions, and Carotid Artery Intima-Media Thickness in Adulthood. Psychosom Med 78:319-26
Muldoon, M F; Laderian, B; Kuan, D C H et al. (2016) Fish oil supplementation does not lower C-reactive protein or interleukin-6 levels in healthy adults. J Intern Med 279:98-109
Joseph, Nataria T; Muldoon, Matthew F; Manuck, Stephen B et al. (2016) The Role of Occupational Status in the Association Between Job Strain and Ambulatory Blood Pressure During Working and Nonworking Days. Psychosom Med 78:940-949
Jennings, J Richard; Sheu, Lei K; Kuan, Dora C-H et al. (2016) Resting state connectivity of the medial prefrontal cortex covaries with individual differences in high-frequency heart rate variability. Psychophysiology 53:444-54
Wong, Patricia M; Manuck, Stephen B; DiNardo, Monica M et al. (2015) Shorter sleep duration is associated with decreased insulin sensitivity in healthy white men. Sleep 38:223-31
Chang, Luke J; Gianaros, Peter J; Manuck, Stephen B et al. (2015) A Sensitive and Specific Neural Signature for Picture-Induced Negative Affect. PLoS Biol 13:e1002180
Richard Jennings, J; Allen, Ben; Gianaros, Peter J et al. (2015) Focusing neurovisceral integration: cognition, heart rate variability, and cerebral blood flow. Psychophysiology 52:214-24

Showing the most recent 10 out of 192 publications