Building on our PPG experiences over the past 17 years, the goal of Core B is ensure achievement of all scientific aims and to provide responsive and effective centralized support services that include: I. Laboratory and II. Database support. The objectives of these support components are to: 1) provide organizational structure; 2) facilitate interaction for enhancing synergy among investigators and projects;and 3) coordinate activities among all projects and Core B Laboratory in an integrated, cost-efficient manner. Achievement of these objectives is facilitated by Core B's shared utilization of resources, services, and personnel. In our PPG renewal, we have anticipated and, accordingly, prepared forthe challenges accompanying our broader scope, greater number of projects, and new performance sites. We foresee new scientific and medical opportunities as we 1) expand our laboratory capabilities to include the new, but related, research focus of one new project - neonatal thrombocytopenia, to respond to the evolving needs of two continuing projects and one new project focused on neonatal anemia;and 2) address a growing need for database management. The challenges presented by the logistics and greater complexity of our expanded program are more than offset by the enhanced opportunities for outstanding team-driven scientific progress and productivity.

Public Health Relevance

Building on our PPG experiences over the past 17 years, the goal of Core B is ensure achievement of all scientific aims and to provide responsive and effective centralized support services that include: I. Laboratory and II. Database support. The objectives of these support components are to: 1) provide organizational structure; 2) facilitate interaction for enhancing synergy among investigators and projects;and 3) coordinate activities among all projects and Core B Laboratory in an integrated, cost-efficient manner. Achievement of these objectives is facilitated by Core B's shared utilization of resources, services, and personnel. In our PPG renewal, we have anticipated and, accordingly, prepared forthe challenges accompanying our broader scope, greater number of projects, and new performance sites. We foresee new scientific and medical opportunities as we 1) expand our laboratory capabilities to include the new, but related, research focus of one new project - neonatal thrombocytopenia, to respond to the evolving needs of two continuing projects and one new project focused on neonatal anemia;and 2) address a growing need for database management. The challenges presented by the logistics and greater complexity of our expanded program are more than offset by the enhanced opportunities for outstanding team-driven scientific progress and productivity.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL046925-16A1
Application #
8324329
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
16
Fiscal Year
2012
Total Cost
$393,398
Indirect Cost
$51,158
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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van 't Erve, Thomas J; Doskey, Claire M; Wagner, Brett A et al. (2014) Heritability of glutathione and related metabolites in stored red blood cells. Free Radic Biol Med 76:107-13
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McCoy, Thomasin E; Conrad, Amy L; Richman, Lynn C et al. (2014) The relationship between brain structure and cognition in transfused preterm children at school age. Dev Neuropsychol 39:226-32
Kuruvilla, Denison J; Nalbant, Demet; Widness, John A et al. (2014) Mean remaining life span: a new clinically relevant parameter to assess the quality of transfused red blood cells. Transfusion 54:2724-9
Khan, Irfan; Zimmerman, Bridget; Brophy, Patrick et al. (2014) Masking of syndrome of inappropriate antidiuretic hormone secretion: the isonatremic syndrome. J Pediatr 165:722-6
Nalbant, Demet; Bhandary, Prasad; Matthews, Nell I et al. (2013) Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion. Pediatr Res 74:592-600

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