Building on our PPG experiences over the past 17 years, the goal of Core B is ensure achievement of all scientific aims and to provide responsive and effective centralized support services that include: I. Laboratory and II. Database support. The objectives of these support components are to: 1) provide organizational structure; 2) facilitate interaction for enhancing synergy among investigators and projects;and 3) coordinate activities among all projects and Core B Laboratory in an integrated, cost-efficient manner. Achievement of these objectives is facilitated by Core B's shared utilization of resources, services, and personnel. In our PPG renewal, we have anticipated and, accordingly, prepared forthe challenges accompanying our broader scope, greater number of projects, and new performance sites. We foresee new scientific and medical opportunities as we 1) expand our laboratory capabilities to include the new, but related, research focus of one new project - neonatal thrombocytopenia, to respond to the evolving needs of two continuing projects and one new project focused on neonatal anemia;and 2) address a growing need for database management. The challenges presented by the logistics and greater complexity of our expanded program are more than offset by the enhanced opportunities for outstanding team-driven scientific progress and productivity.

Public Health Relevance

Building on our PPG experiences over the past 17 years, the goal of Core B is ensure achievement of all scientific aims and to provide responsive and effective centralized support services that include: I. Laboratory and II. Database support. The objectives of these support components are to: 1) provide organizational structure; 2) facilitate interaction for enhancing synergy among investigators and projects;and 3) coordinate activities among all projects and Core B Laboratory in an integrated, cost-efficient manner. Achievement of these objectives is facilitated by Core B's shared utilization of resources, services, and personnel. In our PPG renewal, we have anticipated and, accordingly, prepared forthe challenges accompanying our broader scope, greater number of projects, and new performance sites. We foresee new scientific and medical opportunities as we 1) expand our laboratory capabilities to include the new, but related, research focus of one new project - neonatal thrombocytopenia, to respond to the evolving needs of two continuing projects and one new project focused on neonatal anemia;and 2) address a growing need for database management. The challenges presented by the logistics and greater complexity of our expanded program are more than offset by the enhanced opportunities for outstanding team-driven scientific progress and productivity.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL046925-17
Application #
8491923
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
17
Fiscal Year
2013
Total Cost
$378,049
Indirect Cost
$38,813
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Nalbant, Demet; Cancelas, José A; Mock, Donald M et al. (2017) In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage. Transfusion :
Sparger, Katherine A; Ramsey, Haley; Lorenz, Viola et al. (2017) Developmental differences between newborn and adult mice in response to romiplostim. Platelets :1-8
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Bastian, T W; Duck, K A; Michalopoulos, G C et al. (2017) Eltrombopag, a thrombopoietin mimetic, crosses the blood-brain barrier and impairs iron-dependent hippocampal neuron dendrite development. J Thromb Haemost 15:565-574
Schmidt, Robert L; Mock, Donald M; Franco, Robert S et al. (2017) Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose. Transfusion 57:1488-1496
Peters, Anna L; Beuger, Boukje; Mock, Donald M et al. (2016) Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model. Transfusion 56:1362-9
Ekhaguere, Osayame A; Morriss Jr, Frank H; Bell, Edward F et al. (2016) Predictive factors and practice trends in red blood cell transfusions for very-low-birth-weight infants. Pediatr Res 79:736-41
Brumbaugh, Jane E; Conrad, Amy L; Lee, Jessica K et al. (2016) Altered brain function, structure, and developmental trajectory in children born late preterm. Pediatr Res 80:197-203

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