AND SIGNIFICANCE All four Projects in the PPG require expertise in thiol-based redox regulation and/or selenoproteins. The proposed Core C leadership has a strong track record in precisely these areas, as well as in collaborative research in general. Core C is among the few groups in the world with the necessary knowledge, expertise, instrumentation, and reagents to carry out experiments on thiol-based redox processes and selenoproteins;and has a collection of unique tools by which to do so. The Core will aid in the design of relevant experiments and their interpretation.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Brown, Jonathan D; Lin, Charles Y; Duan, Qiong et al. (2014) NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell 56:219-31
Lee, Samuel; Min Kim, Soo; Dotimas, James et al. (2014) Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress. EMBO Mol Med 6:732-43
Taqueti, Viviany R; Di Carli, Marcelo F; Jerosch-Herold, Michael et al. (2014) Increased microvascularization and vessel permeability associate with active inflammation in human atheromata. Circ Cardiovasc Imaging 7:920-9
Zhao, Yuzheng; Yang, Yi; Loscalzo, Joseph (2014) Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors. Methods Enzymol 542:349-67
Chatzizisis, Yiannis S; Blankstein, Ron; Libby, Peter (2014) Inflammation goes with the flow: implications for non-invasive identification of high-risk plaque. Atherosclerosis 234:476-8
Barroso, Madalena; Florindo, Cristina; Kalwa, Hermann et al. (2014) Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem 289:15350-62
Nallamshetty, Shriram; Le, Phuong T; Wang, Hong et al. (2014) Retinaldehyde dehydrogenase 1 deficiency inhibits PPAR?-mediated bone loss and marrow adiposity. Bone 67:281-91
Folco, Eduardo J; Sukhova, Galina K; Quillard, Thibaut et al. (2014) Moderate hypoxia potentiates interleukin-1? production in activated human macrophages. Circ Res 115:875-83
Kalwa, Hermann; Sartoretto, Juliano L; Martinelli, Roberta et al. (2014) Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Natl Acad Sci U S A 111:3383-8
Shiroto, Takashi; Romero, Natalia; Sugiyama, Toru et al. (2014) Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS One 9:e87871

Showing the most recent 10 out of 197 publications