CORE B - COMPUTER SERVICES, INSTRUMENTATION AND IMAGING CORE SUMMARY/ABSTRACT Core B will provided centralized technical support for the computer, electronic and imaging services needed for collection and analysis of experimental data. The services are an essential part of the protocol design, animal maintenance, data acquisition and data analyses of Projects I, II, and III. The experiments proposed in the current application require chronic measurements of cardiovascular variables in rats and mice. By providing leadership and technical support to all members of the PPG, we are able to provide sophisticated data collection and imaging systems to investigators in a timely and fiscally efficient manner. Core B will provide systems analysis and computer simulation services to assist investigators in understanding the integrative aspects of the mechanisms that are elucidated by each of the projects. Core B provides a variety of shared imaging technologies to all investigators on the Program Project Grant, so that high quality measurements can be made at a lower cost. Core B facilities and services are available to all members of the Program Project Grant and continue to be critical for the success of all projects in the current proposal. Personnel in Core B are readily available to provide expert technical support as well as assistance with the operation of any equipment or instrumentation within the core. This Core will lead to increased productivity of the Program Project Grant.
CORE B - COMPUTER SERVICES, INSTRUMENTATION AND IMAGING CORE NARRATIVE Obesity and its cardiovascular and metabolic consequences, including hypertension, are major health issues affecting a large fraction of the US population. This Program Project Grant will provide new information about the underlying mechanisms by which obesity contributes to increased blood pressure and metabolic disorders in experimental models that are highly relevant to common, and difficult to treat, forms of human hypertension caused by obesity, preeclampsia, and postmenopausal hyperandrogenemia. This Core will provide technical expertise, mathematical modeling, computer services and imaging that will allow us to understand the pathogenesis of these disorders and to accomplish our long-term goal of developing a comprehensive systems analysis of cardiovascular dynamics and their control.
|Jung, Mira; Ma, Yonggang; Iyer, Rugmani Padmanabhan et al. (2017) IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation. Basic Res Cardiol 112:33|
|Ma, Yonggang; Iyer, Rugmani Padmanabhan; Jung, Mira et al. (2017) Cardiac Fibroblast Activation Post-Myocardial Infarction: Current Knowledge Gaps. Trends Pharmacol Sci 38:448-458|
|Feng, Ruiqi; Liu, Jia; Wang, Zhenhua et al. (2017) The structure-activity relationship of ginsenosides on hypoxia-reoxygenation induced apoptosis of cardiomyocytes. Biochem Biophys Res Commun 494:556-568|
|Muntner, Paul; Abdalla, Marwah; Correa, Adolfo et al. (2017) Hypertension in Blacks: Unanswered Questions and Future Directions for the JHS (Jackson Heart Study). Hypertension 69:761-769|
|Chade, Alejandro R (2017) Small Vessels, Big Role: Renal Microcirculation and Progression of Renal Injury. Hypertension 69:551-563|
|Drummond, Heather A; Xiang, Lusha; Chade, Alejandro R et al. (2017) Enhanced maximal exercise capacity, vasodilation to electrical muscle contraction, and hind limb vascular density in ASIC1a null mice. Physiol Rep 5:|
|Faulkner, Jessica L; Amaral, Lorena M; Cornelius, Denise C et al. (2017) Vitamin D supplementation reduces some AT1-AA-induced downstream targets implicated in preeclampsia including hypertension. Am J Physiol Regul Integr Comp Physiol 312:R125-R131|
|Blair, Evan T; Clemmer, John S; Harkey, H Louis et al. (2017) Physiologic Mechanisms of Water and Electrolyte Disturbances After Transsphenoidal Pituitary Surgery. World Neurosurg 107:429-436|
|Bakrania, Bhavisha A; Spradley, Frank T; Satchell, Simon C et al. (2017) Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells. Am J Physiol Regul Integr Comp Physiol :|
|Taylor, Erin B; Ryan, Michael J (2017) Immunosuppression With Mycophenolate Mofetil Attenuates Hypertension in an Experimental Model of Autoimmune Disease. J Am Heart Assoc 6:|
Showing the most recent 10 out of 723 publications