Program administration is centralized in Core A to promote synergistic interaction between clinical and laboratory projects and to provide strong leadership for the Program. As described in the Program Introduction, Dr. Sorrentino, the Program Principal Investigator, has primary responsibility for the overall coordination of the Program Project, including the three projects and four core components. The Administration Core will provide key functions to assist Dr. Sorrentino in guiding and supervising this Program. One such function will be organizing the Hematology Research Seminar Series, which meets every two weeks and includes all academic personnel that participate in the Program. The Administration Core will also provide support for our External Advisory Committee, which will travel to St. Jude once a year in years 2-5 in order to review our progress and critique the projects and cores. This Core will provide general administrative support for the program including assistance in preparing and submitting yearly non-competitive renewals, assist in preparation of manuscripts, and provide for travel arrangements for Project and Core leaders to travel to scientific meetings and present their results. The Administration Core will also provide for budgetary oversight, ordering of supplies, provide administrative oversight for the subcontracts in this Program, and provide with general secretarial support for the Project and Core leaders.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL053749-19
Application #
8531320
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2015-07-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
19
Fiscal Year
2013
Total Cost
$342,061
Indirect Cost
$137,758
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Yu, Hui; Neale, Geoffrey; Zhang, Hui et al. (2014) Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo. Blood 124:1737-47
Jackson, Shaun W; Scharping, Nicole E; Kolhatkar, Nikita S et al. (2014) Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J Immunol 192:4525-32
Griffith, Linda M; Cowan, Morton J; Notarangelo, Luigi D et al. (2014) Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol 133:335-47
Treanor, Louise M; Zhou, Sheng; Janke, Laura et al. (2014) Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med 211:701-13
De Ravin, Suk See; Gray, John T; Throm, Robert E et al. (2014) False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector. Mol Ther 22:244-5
Nienhuis, Arthur W (2013) Development of gene therapy for blood disorders: an update. Blood 122:1556-64
Zhou, Sheng; Ma, Zhijun; Lu, Taihe et al. (2013) Mouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vector. PLoS One 8:e62333
Wilber, Andrew; Nienhuis, Arthur W; Persons, Derek A (2011) Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities. Blood 117:3945-53
Wilber, Andrew; Hargrove, Phillip W; Kim, Yoon-Sang et al. (2011) Therapeutic levels of fetal hemoglobin in erythroid progeny of ýý-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood 117:2817-26
Kim, Yoon-Sang; Wielgosz, Matthew M; Hargrove, Phillip et al. (2010) Transduction of human primitive repopulating hematopoietic cells with lentiviral vectors pseudotyped with various envelope proteins. Mol Ther 18:1310-7

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