Abstract

The purpose of the Clinical Core is to provide critical support for individual projects, including (1) assistance with recruitment and screening of normal subjects, (2) the identification of patients with specific autonomic disorders, (3) nursing and paramedical support for the performance of individual studies, and (4) the management of clinical resources (equipment and space) in a cost-effective manner. Shared study rooms and equipment permit flexibility and will maximize the availability of computer data acquisition systems, and specialized equipment. The Clinical Core supports state-of-the-art techniques for the functional assessment of autonomic function in man. The Core has implemented new methods and techniques relevant to the study of cardiovascular regulation, and continues to develop novel approaches to the analysis of complex biomedical signals, which can be now applied to support individual projects.

Public Health Relevance

The purpose of the Clinical Core (Core B) is to provide shared resources, equipment, techniques and support personnel to all investigators in this Program Project Grant. This is more cost-effective than having each project develop their own methodologies, and assures greater quality control.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL056693-17
Application #
8458079
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
17
Fiscal Year
2013
Total Cost
$208,857
Indirect Cost
$74,692

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Mar, Philip L; Raj, Satish R (2018) Orthostatic hypotension for the cardiologist. Curr Opin Cardiol 33:66-72
Chaugai, Sandip; Dickson, Alyson L; Shuey, Megan M et al. (2018) Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study. Clin Pharmacol Ther :
van den Berg, Maarten P; Almomani, Rowida; Biaggioni, Italo et al. (2018) Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome. Circ Res 122:846-854
Mai, Tu H; Garland, Emily M; Diedrich, André et al. (2017) Hepatic and renal mechanisms underlying the osmopressor response. Auton Neurosci 203:58-66
Kawai, V K; Levinson, R T; Adefurin, A et al. (2017) A genetic risk score that includes common type 2 diabetes risk variants is associated with gestational diabetes. Clin Endocrinol (Oxf) 87:149-155
Pezawas, Thomas; Diedrich, André; Robertson, David et al. (2017) Risk of arrhythmic death in ischemic heart disease: a prospective, controlled, observer-blind risk stratification over 10 years. Eur J Clin Invest 47:231-240
Adefurin, A; Ghimire, L V; Kohli, U et al. (2017) Genetic variation in the alpha1B-adrenergic receptor and vascular response. Pharmacogenomics J 17:366-371
Kaufman, Melissa R; Chang-Kit, Laura; Raj, Satish R et al. (2017) Overactive bladder and autonomic dysfunction: Lower urinary tract symptoms in females with postural tachycardia syndrome. Neurourol Urodyn 36:610-613
Shaw, Brett H; Garland, Emily M; Black, Bonnie K et al. (2017) Optimal diagnostic thresholds for diagnosis of orthostatic hypotension with a 'sit-to-stand test'. J Hypertens 35:1019-1025
Kawai, Vivian K; Levinson, Rebecca T; Adefurin, Abiodun et al. (2017) Variation in the ?2A-adrenergic receptor gene and risk of gestational diabetes. Pharmacogenomics 18:1381-1386

Showing the most recent 10 out of 315 publications