All of the projects within this Program, require the analysis of embryonic and/or adult murine tissues. The plan is to use the Tissue Core facilitates of the UCSD Cancer Center for routine histology, immunohistochemistry or in situ hybridization to analyse the various tissues obtained from the different projects. The facility is already set up and most of the major equipment is in place. Some methodologies will be modified or optimized specially for this program.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL057345-01A1
Application #
6242810
Study Section
Project Start
1997-09-30
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sato, Emi; Zhang, Ling-Juan; Dorschner, Robert A et al. (2017) Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol 137:1774-1783
Johns, Scott C; Yin, Xin; Jeltsch, Michael et al. (2016) Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis. Circ Res 119:210-21
Mooij, Hans L; Bernelot Moens, Sophie J; Gordts, Philip L S M et al. (2015) Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res 56:665-73
Kawamura, Tetsuya; Stephens, Bryan; Qin, Ling et al. (2014) A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One 9:e81454
Muto, Jun; Morioka, Yasuhide; Yamasaki, Kenshi et al. (2014) Hyaluronan digestion controls DC migration from the skin. J Clin Invest 124:1309-19
Mooij, H L; Cabrales, P; Bernelot Moens, S J et al. (2014) Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc 3:e001274
Yin, Xin; Johns, Scott C; Kim, Daniel et al. (2014) Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol 192:2133-42
Chang, Yung-Chi; Olson, Joshua; Beasley, Federico C et al. (2014) Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog 10:e1003846
Schommer, Nina N; Muto, Jun; Nizet, Victor et al. (2014) Hyaluronan breakdown contributes to immune defense against group A Streptococcus. J Biol Chem 289:26914-21
Xu, Ding; Young, Jeffrey H; Krahn, Juno M et al. (2013) Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol 8:1611-20

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