Abstract

Objective: The purpose of the Administrative Core Unit is to provide overall direction and oversight of the Program, promote interaction among the investigators, and provide effective budget management and administrative assistance. Description: The offices of Dr. Shattil and Tawana Young are located immediately adjacent to the laboratories of Dr. Shattil and Ginsberg. The program will require extensive interactions between the participants, as well as access to the central UCSD electronic mail system, computing facilities and fiscal management software. The Administrative Core Unit will coordinate the monitoring of research within and between projects, optimize utilization of the other core units, interact with departmental and UCSD fund managers, schedule """"""""work-in-progress"""""""" research meetings and meetings of the Advisory Boards, and prepare reports to the NIH.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL057900-16
Application #
8374732
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2014-01-31
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
16
Fiscal Year
2012
Total Cost
$43,913
Indirect Cost
$15,490

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Wilson, RaeAnna; Espinosa-Diez, Cristina; Kanner, Nathan et al. (2016) MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun 7:13597
Liao, Zhongji; Kato, Hisashi; Pandey, Manjula et al. (2015) Interaction of kindlin-2 with integrin ?3 promotes outside-in signaling responses by the ?V?3 vitronectin receptor. Blood 125:1995-2004
Desgrosellier, Jay S; Lesperance, Jacqueline; Seguin, Laetitia et al. (2014) Integrin ?v?3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell 30:295-308
Fitzpatrick, Paul; Shattil, Sanford J; Ablooglu, Ararat J (2014) C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein. J Biol Chem 289:11183-93
Seguin, Laetitia; Kato, Shumei; Franovic, Aleksandra et al. (2014) An integrin ??-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol 16:457-68
Casar, B; Rimann, I; Kato, H et al. (2014) In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated ?1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene 33:255-68
Ye, Feng; Petrich, Brian G; Anekal, Praju et al. (2013) The mechanism of kindlin-mediated activation of integrin ?IIb?3. Curr Biol 23:2288-2295
Scheppke, Lea; Murphy, Eric A; Zarpellon, Alessandro et al. (2012) Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood 119:2149-58
Cantor, Joseph M; Ginsberg, Mark H (2012) CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci 125:1373-82
Banno, Asoka; Goult, Benjamin T; Lee, HoSup et al. (2012) Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem 287:13799-812

Showing the most recent 10 out of 79 publications