The Small Animal Core: Models of Acute Lung Injury (ALI) will provide two major core functions to support the PPG's research investigators and five research projects. The first function is providing murine models of ALI (LPS- and vertilator-induced) with the core ensuring reproducible studies with a complete range of expertise and tools to obtain critical information pertaining to the cellular and molecular basis of endothelial barrier permeability. The Core, using well published techniques and parameters of acute lung injury, will employ state-of-the-art evaluation of pulmonary pathophysiology, interventions, data analysis, and interpretation, in order to provide insight into the efficacy and mechanisms of clinically relevant management approaches and to facilitate the translation of basic research to the clinical arena. The Core will take advantage of the resources available at the University of Chicago Small Animal Imaging core (which includes MRI, CT Optical Imaging, etc. This Core provides quantitative measurements of permeability, inflammation, edema, vascular leak and biomarkers. A second core function is to care for the wild type and geneticallyengineered mice utilized in this Program and to generate novel transgenic mice where indicated. Core leaders have assembled talented and well published personnel and enjoy newly built laboratory facilities to satisfy a wide range of experimental physiological and imaging needs. Core C personnel have professional experience spanning the fields of physiology, microsurgery, biology, and animal care and has already provided convincing evidence of coherent interactions with investigators of all five research projects delivering key preliminary results related to our PPG projects.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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University of Illinois at Chicago
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Tao, Shasha; Rojo de la Vega, Montserrat; Quijada, Hector et al. (2016) Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner. Sci Rep 6:18760
de la Vega, Montserrat Rojo; Dodson, Matthew; Gross, Christine et al. (2016) Role of Nrf2 and Autophagy in Acute Lung Injury. Curr Pharmacol Rep 2:91-101
Camp, Sara M; Chiang, Eddie T; Sun, Chaode et al. (2016) ""Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720"". Chem Phys Lipids 194:85-93
Viswanathan, P; Ephstein, Y; Garcia, J G N et al. (2016) Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. Biochem Biophys Res Commun 478:599-605
Letsiou, E; Rizzo, A N; Sammani, S et al. (2015) Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 308:L259-69
Letsiou, Eleftheria; Sammani, Saad; Zhang, Wei et al. (2015) Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding. Am J Respir Cell Mol Biol 52:193-204
Wang, Xin; Bleher, Reiner; Brown, Mary E et al. (2015) Nano-Biomechanical Study of Spatio-Temporal Cytoskeleton Rearrangements that Determine Subcellular Mechanical Properties and Endothelial Permeability. Sci Rep 5:11097
Choi, Sangwook; Camp, Sara M; Dan, Arkaprava et al. (2015) A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing. Am J Physiol Lung Cell Mol Physiol 309:L983-94
Shen, Kui; Ramirez, Benjamin; Mapes, Brandon et al. (2015) Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants. PLoS One 10:e0130515
Wang, Lichun; Bittman, Robert; Garcia, Joe G N et al. (2015) Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate. Microvasc Res 99:102-9

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