This Program Project consists of three individual related research projects and three cores. This core oversees the administrative needs of the program. The Program Project director (Dr. Warshaw) will maintain a staff who are responsible for financial records, progress reports, internal documents necessary for the functioning of the program project, interfacing with the subcontract business officers and administrative assistants and Project and Core leaders at the off-site institutions, and computer hardware, network, and software support.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL059408-15
Application #
8611949
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
15
Fiscal Year
2014
Total Cost
$320,835
Indirect Cost
$104,920
Name
University of Vermont & St Agric College
Department
Type
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Lee, Kyounghwan; Harris, Samantha P; Sadayappan, Sakthivel et al. (2015) Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM. J Mol Biol 427:274-86
Sandri, Marco; Robbins, Jeffrey (2014) Proteotoxicity: an underappreciated pathology in cardiac disease. J Mol Cell Cardiol 71:3-10
Rainer, Peter P; Hao, Scarlett; Vanhoutte, Davy et al. (2014) Cardiomyocyte-specific transforming growth factor ? suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction. Circ Res 114:1246-57
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Mun, Ji Young; Previs, Michael J; Yu, Hope Y et al. (2014) Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism. Proc Natl Acad Sci U S A 111:2170-5
Yang, Shixin; Barbu-Tudoran, Lucian; Orzechowski, Marek et al. (2014) Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state. Biophys J 106:855-64
Craig, Roger; Lee, Kyoung Hwan; Mun, Ji Young et al. (2014) Structure, sarcomeric organization, and thin filament binding of cardiac myosin-binding protein-C. Pflugers Arch 466:425-31
Tanner, Bertrand C W; Wang, Yuan; Robbins, Jeffrey et al. (2014) Kinetics of cardiac myosin isoforms in mouse myocardium are affected differently by presence of myosin binding protein-C. J Muscle Res Cell Motil 35:267-78
Wang, Xuejun; Robbins, Jeffrey (2014) Proteasomal and lysosomal protein degradation and heart disease. J Mol Cell Cardiol 71:16-24

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