Core C, the Mouse Breeding and Microsurgery and Procedure Core will continue to serve all three Projects over all five years of the Program. There are two major functions of Core C: (1) The Mouse Breeding & Management Unit will continue to provide transgenic and null mice bred Into specific genetic backgrounds to each of the three projects of the Program. This Unit will provide sen/ices to mate and genotype the animals required for Projects 1-2-3. (2) The newly-formed Mouse Microsurgery and Procedure Unit has grown out of the expansion of the Program's studies. The goal of this Unit is to standardize all microsurgery procedures and procedures carried out by the Projects. This Unit will be responsible for lethal irradiation and bone marrow transplantation (Projects 2), femoral artery ligation for induction of hind limb ischemia (Project 2), assessment of reverse cholesterol transport (Project 1) and myocardial infarction (Project 3).
Atherosclerosis, peripheral arterial disease and myocardial infarction and its consequences are highlyprevalent diseases. In subjects with diabetes, the incidence and severity of these disorders is increased. This application focuses on the Receptor for Advanced Glycation Endproducts (RAGE) and its biology in accelerated cardiovascular disease, particulariy in diabetes.
|LÃ³pez-DÃez, Raquel; Shekhtman, Alexander; Ramasamy, Ravichandran et al. (2016) Cellular mechanisms and consequences of glycation in atherosclerosis and obesity. Biochim Biophys Acta 1862:2244-2252|
|Ramasamy, Ravichandran; Shekhtman, Alexander; Schmidt, Ann Marie (2016) The multiple faces of RAGE--opportunities for therapeutic intervention in aging and chronic disease. Expert Opin Ther Targets 20:431-46|
|Thiagarajan, Devi; Vedantham, Srinivasan; Ananthakrishnan, Radha et al. (2016) Mechanisms of transcription factor acetylation and consequences in hearts. Biochim Biophys Acta 1862:2221-2231|
|Manigrasso, Michaele B; Pan, Jinhong; Rai, Vivek et al. (2016) Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction. Sci Rep 6:22450|
|Thiagarajan, Devi; Ananthakrishnan, Radha; Zhang, Jinghua et al. (2016) Aldose Reductase Acts as a Selective Derepressor of PPARÎ³ and the Retinoic Acid Receptor. Cell Rep 15:181-96|
|Schmidt, Ann Marie (2015) Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease. Vascul Pharmacol 72:1-8|
|Zirpoli, Hylde; Abdillahi, Mariane; Quadri, Nosirudeen et al. (2015) Acute administration of n-3 rich triglyceride emulsions provides cardioprotection in murine models after ischemia-reperfusion. PLoS One 10:e0116274|
|Gao, Minghui; Monian, Prashant; Quadri, Nosirudeen et al. (2015) Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell 59:298-308|
|Schmidt, Ann Marie (2015) The growing problem of obesity: mechanisms, consequences, and therapeutic approaches. Arterioscler Thromb Vasc Biol 35:e19-23|
|Grossin, Nicolas; Auger, Florent; Niquet-Leridon, CÃ©line et al. (2015) Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice. Mol Nutr Food Res 59:927-38|
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