The purpose of the Animal Models Core is to provide chronic animals necessary for the projects and insure consistency in animal models across the various projects in this PPG. This will eliminate the variability of preparations and will release the individual Project Directors from the extremely labor intensive task of creating chronic animals and caring for their immediate post operative recovery. The Core will also provide echocardiographic assessment on animals prior to and during the development of heart failure or sham time controls. The Animal Models Core has worked very effectively over the past 10 years of this PPG. Various animal models will be prepared by or under the supervision of Dr. Kurtis G. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. He will be assisted by three technicians in the preparation and care of animals prior to their use by the PPG investigators. The models prepared by this Core will be (1) the coronary ligation model of heart failure (HF) in the rat, and (2) the pacing model of HF in the rabbit. Assessment of the cardiac status of all animals is obtained echocardiographically. The Core is supported by two echocardiographs. Rabbit imaging is done on an Accuson Sequoia 5120 machine and rodent images are obtained on a Visual Sonics Vevo 770. Ms. Johnnie Hackley is primarily responsible for obtaining the data on the rats and rabbits prior to, during and after the induction of heart failure.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Nebraska Medical Center
United States
Zip Code
Zheng, Hong; Liu, Xuefei; Sharma, Neeru M et al. (2016) Urinary Proteolytic Activation of Renal Epithelial Na+ Channels in Chronic Heart Failure. Hypertension 67:197-205
Zheng, Hong; Patel, Kaushik P (2016) Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow. Auton Neurosci :
Patel, Kaushik P; Xu, Bo; Liu, Xuefei et al. (2016) Renal Denervation Improves Exaggerated Sympathoexcitation in Rats With Heart Failure: A Role for Neuronal Nitric Oxide Synthase in the Paraventricular Nucleus. Hypertension 68:175-84
Vaz, Gisele C; Sharma, Neeru M; Zheng, Hong et al. (2016) Liposome-entrapped GABA modulates the expression of nNOS in NG108-15 cells. J Neurosci Methods 273:55-63
Schiller, Alicia M; Pellegrino, Peter Ricci; Zucker, Irving H (2016) Eppur Si Muove: The dynamic nature of physiological control of renal blood flow by the renal sympathetic nerves. Auton Neurosci :
Pellegrino, Peter R; Schiller, Alicia M; Haack, Karla K V et al. (2016) Central Angiotensin-II Increases Blood Pressure and Sympathetic Outflow via Rho Kinase Activation in Conscious Rabbits. Hypertension 68:1271-1280
Stern, Javier E; Son, Sookjin; Biancardi, Vinicia C et al. (2016) Astrocytes Contribute to Angiotensin II Stimulation of Hypothalamic Neuronal Activity and Sympathetic Outflow. Hypertension 68:1483-1493
Ardell, J L; Andresen, M C; Armour, J A et al. (2016) Translational neurocardiology: preclinical models and cardioneural integrative aspects. J Physiol 594:3877-909
Pügge, Carolin; Mediratta, Jai; Marcus, Noah J et al. (2016) Exercise training normalizes renal blood flow responses to acute hypoxia in experimental heart failure: role of the α1-adrenergic receptor. J Appl Physiol (1985) 120:334-43
Sharma, Neeru M; Cunningham, Craig J; Zheng, Hong et al. (2016) Hypoxia-Inducible Factor-1α Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-d-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure. Circ Heart Fail 9:

Showing the most recent 10 out of 152 publications