The purpose of the Animal Models Core is to provide chronic animals necessary for the projects and insure consistency in animal models across the various projects in this PPG. This will eliminate the variability of preparations and will release the individual Project Directors from the extremely labor intensive task of creating chronic animals and caring for their immediate post operative recovery. The Core will also provide echocardiographic assessment on animals prior to and during the development of heart failure or sham time controls. The Animal Models Core has worked very effectively over the past 10 years of this PPG. Various animal models will be prepared by or under the supervision of Dr. Kurtis G. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. He will be assisted by three technicians in the preparation and care of animals prior to their use by the PPG investigators. The models prepared by this Core will be (1) the coronary ligation model of heart failure (HF) in the rat, and (2) the pacing model of HF in the rabbit. Assessment of the cardiac status of all animals is obtained echocardiographically. The Core is supported by two echocardiographs. Rabbit imaging is done on an Accuson Sequoia 5120 machine and rodent images are obtained on a Visual Sonics Vevo 770. Ms. Johnnie Hackley is primarily responsible for obtaining the data on the rats and rabbits prior to, during and after the induction of heart failure.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062222-15
Application #
8509766
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
1999-07-05
Project End
2014-08-31
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2013
Total Cost
$217,100
Indirect Cost
$70,904
Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Haack, Karla K V; Zucker, Irving H (2015) Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure. Auton Neurosci 188:44-50
Wang, Han-Jun; Wang, Wei; Cornish, Kurtis G et al. (2014) Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension 64:745-55
Zucker, Irving H; Xiao, Liang; Haack, Karla K V (2014) The central renin-angiotensin system and sympathetic nerve activity in chronic heart failure. Clin Sci (Lond) 126:695-706
Haack, Karla K V; Marcus, Noah J; Del Rio, Rodrigo et al. (2014) Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure. Hypertension 63:1041-9
Marcus, Noah J; Del Rio, Rodrigo; Schultz, Evan P et al. (2014) Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure. J Physiol 592:391-408
Pellegrino, Peter R; Schiller, Alicia M; Zucker, Irving H (2014) Validation of pulse rate variability as a surrogate for heart rate variability in chronically instrumented rabbits. Am J Physiol Heart Circ Physiol 307:H97-109
Llewellyn, Tamra L; Sharma, Neeru M; Zheng, Hong et al. (2014) Effects of exercise training on SFO-mediated sympathoexcitation during chronic heart failure. Am J Physiol Heart Circ Physiol 306:H121-31
Sharma, Neeru M; Llewellyn, Tamra L; Zheng, Hong et al. (2013) Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN. Am J Physiol Heart Circ Physiol 305:H843-55
Zheng, Hong; Liu, Xuefei; Patel, Kaushik P (2013) Centrally mediated erectile dysfunction in rats with type 1 diabetes: role of angiotensin II and superoxide. J Sex Med 10:2165-76
Schiller, Alicia M; Haack, Karla K V; Pellegrino, Peter R et al. (2013) Unilateral renal denervation improves autonomic balance in conscious rabbits with chronic heart failure. Am J Physiol Regul Integr Comp Physiol 305:R886-92

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