Abstract

This Program Project will be administered at the level of the University of Pennsylvania by the Office of Research Administration under the direction of Ms. Pamela Caudill. The Program includes a consortium arrangement with the Wistar Institute, which is a corporate entity separate from the University of Pennsylvania. Similar consortium arrangements presently exist between the two institutions and the financial and administrative officers of each are experienced in the efficient management of such arrangements. The participants in this Program Project are members of the faculty of the Medical School of the University of Pennsylvania. Thus, they have access to all of the resources of the institution.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062250-14
Application #
8375999
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$77,257
Indirect Cost
$28,971

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Paschos, Georgios K; Tang, Soon Yew; Theken, Katherine N et al. (2018) Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2. Cell Rep 24:809-814
Davies, Peter F; Manduchi, Elisabetta; Jiménez, Juan M et al. (2017) Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression. J Biomech 50:3-10
Davies, Peter F; Manduchi, Elisabetta; Stoeckert, Christian J et al. (2016) SY 15-2 ENDOTHELIAL EPIGENETICS AND ITS ROLE IN MEDIATING BIOMECHANICAL STRESS OF HYPERTENSION. J Hypertens 34 Suppl 1 - IS:e371
Bae, Yong Ho; Liu, Shu-Lin; Byfield, Fitzroy J et al. (2016) Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy. J Vis Exp :
Tang, Soon Yew; Monslow, James; R Grant, Gregory et al. (2016) Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice. Circulation 134:328-38
Hsu, Bernadette Y; Bae, Yong Ho; Mui, Keeley L et al. (2015) Apolipoprotein E3 Inhibits Rho to Regulate the Mechanosensitive Expression of Cox2. PLoS One 10:e0128974
Han, Jingyan; Shuvaev, Vladimir V; Davies, Peter F et al. (2015) Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Control Release 210:39-47
Jiang, Yi-Zhou; Manduchi, Elisabetta; Jiménez, Juan M et al. (2015) Endothelial epigenetics in biomechanical stress: disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35:1317-26
Liu, Shu-Lin; Bae, Yong Ho; Yu, Christopher et al. (2015) Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening. Sci Rep 5:17189
Sweet, Daniel T; Jiménez, Juan M; Chang, Jeremy et al. (2015) Lymph flow regulates collecting lymphatic vessel maturation in vivo. J Clin Invest 125:2995-3007

Showing the most recent 10 out of 163 publications