1. Surgical Animal Models for Studying Cardiac Hypertrophy and Failure The Director of the Animal Physiology Core has developed a number of surgical models that induce cardiac hypertrophy and failure in the rodent. In Projects 1,2 and 3 (Solaro, Russell, Lewandowski), transverse thoracic aortic banding will be used to examine the effect of superimposing a systolic pressure overload on mice that overexpress transgenes of sarcomeric and intracellular signaling proteins in the heart. Project 2 also includes a model of arteriovenous insufficiency in mice to induce a volume overload on the left ventricle. Guinea pigs (DeTombe, Project 4) will be subjected to pressure and volume overload induced by transverse thoracic aortic coarctation or aortic insufficiency (aortic valve leaflet damage). These studies will examine the effect of ventricular remodeling and failure on isolated muscle function and the role that phosphorylation of sarcomeric proteins play in cardiac dysfunction.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062426-14
Application #
8467014
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
14
Fiscal Year
2013
Total Cost
$452,644
Indirect Cost
$106,355
Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
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Wang, Rui; Wang, Yanwen; Lin, Wee K et al. (2014) Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide. PLoS One 9:e101974

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