Abstract

The overall objective of the Transgenic and Homologous Recombination Core is to provide program project investigators with the ability to utilize animal models in the execution of their proposed research projects as well as establish new animal models in the execution of their proposed research projects as well as establish new animal models for the investigation of the mechanisms involved in the regulation of cardiac development. Although the use of mouse models provide an invaluable source of reagents for investigating regulatory mechanisms Transgenic and Homologous Recombination Core will serve as a resource for the execution and training the use of all animal manipulations needed in this Program Project proposal. The Transgenic and Homologous Recombination Core will minimize the cost of utilizing animal models in this Program Project by consolidating the equipment, expertise and animal resources. This will ensure an efficient use of Animal research at minimal cost.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL067155-02
Application #
6602712
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Towbin, Jeffrey A (2014) Ion channel dysfunction associated with arrhythmia, ventricular noncompaction, and mitral valve prolapse: a new overlapping phenotype. J Am Coll Cardiol 64:768-71
Comar, M; D'Agaro, P; Campello, C et al. (2009) Human herpes virus 6 in archival cardiac tissues from children with idiopathic dilated cardiomyopathy or congenital heart disease. J Clin Pathol 62:80-3
Verzi, Michael P; Stanfel, Monique N; Moses, Kelvin A et al. (2009) Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology 136:1701-10
Zhu, Lirong; Zhou, Guisheng; Poole, Suzanne et al. (2008) Characterization of the interactions of human ZIC3 mutants with GLI3. Hum Mutat 29:99-105
Zhu, Lirong; Peng, Jian Lan; Harutyunyan, Karine G et al. (2007) Craniofacial, skeletal, and cardiac defects associated with altered embryonic murine Zic3 expression following targeted insertion of a PGK-NEO cassette. Front Biosci 12:1680-90
Zhu, Lirong; Harutyunyan, Karine G; Peng, Jian Lan et al. (2007) Identification of a novel role of ZIC3 in regulating cardiac development. Hum Mol Genet 16:1649-60
Cox, Gerald F; Sleeper, Lynn A; Lowe, April M et al. (2006) Factors associated with establishing a causal diagnosis for children with cardiomyopathy. Pediatrics 118:1519-31
Towbin, Jeffrey A; Lowe, April M; Colan, Steven D et al. (2006) Incidence, causes, and outcomes of dilated cardiomyopathy in children. JAMA 296:1867-76
Lu, C-W; Lin, J-H; Rajawat, Y S et al. (2006) Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome. J Med Genet 43:653-9
Zhang, Zhen; Huynh, Tuong; Baldini, Antonio (2006) Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development 133:3587-95

Showing the most recent 10 out of 29 publications