The primary purpose of the Biochemical and Molecular Biology Core (Core C) is to centralize support for techniques that are common to a majority of the individual projects with this Program Project Grant application. This core is thus an important resource for the investigators of this application, the individuals in their laboratories and is an essential part of this Program Project. This core will provide project investigators with technical support, teaching, upkeep of particular key pieces of equipment and centralize supply sources for commonly-used molecular and biochemical techniques. We have also developed a repository of methods/protocols kept electronically through the PPG website, protocols that are available to all participants in the program. We will continue to develop additional techniques for measurement of reactive oxygen species (ROS), use of HPLC, etc.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL070687-10
Application #
8452157
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2015-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
10
Fiscal Year
2013
Total Cost
$173,444
Indirect Cost
$59,314
Name
Michigan State University
Department
Type
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Jackson, William F (2016) Boosting the signal: Endothelial inward rectifier K(+) channels. Microcirculation :
Matin, Nusrat; Fisher, Courtney; Jackson, William F et al. (2016) Bilateral common carotid artery stenosis in normotensive rats impairs endothelium-dependent dilation of parenchymal arterioles. Am J Physiol Heart Circ Physiol 310:H1321-9
Hammond, Bradley; Kreulen, David L (2016) Gene Therapy of the Peripheral Nervous System: Celiac Ganglia. Methods Mol Biol 1382:275-83
Ismail, Alex; Ayala-Lopez, Nadia; Ahmad, Maleeha et al. (2016) 3T3-L1 cells and perivascular adipocytes are not equivalent in amine transporter expression. FEBS Lett :
Seitz, Bridget M; Krieger-Burke, Teresa; Fink, Gregory D et al. (2016) Serial Measurements of Splanchnic Vein Diameters in Rats Using High-Frequency Ultrasound. Front Pharmacol 7:116
Matin, Nusrat; Pires, Paulo W; Garver, Hannah et al. (2016) DOCA-salt hypertension impairs artery function in rat middle cerebral artery and parenchymal arterioles. Microcirculation 23:571-579
Jackson, William F (2016) Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action? J Physiol 594:5055-77
Diaz-Otero, Janice M; Garver, Hannah; Fink, Gregory D et al. (2016) Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles. Am J Physiol Heart Circ Physiol 310:H365-75
Xu, Hui; Garver, Hannah; Fernandes, Roxanne et al. (2015) BK channel β1-subunit deficiency exacerbates vascular fibrosis and remodelling but does not promote hypertension in high-fat fed obesity in mice. J Hypertens 33:1611-23
Pires, Paulo W; Jackson, William F; Dorrance, Anne M (2015) Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. Am J Physiol Heart Circ Physiol 309:H127-36

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