The Administrative Core provides the infrastructure and basic support for Projects I, II and III and Cores A and B to conduct their experiments and accomplish their research objectives. This core will serve as the common channel through which all scientific, administrative and fiscal communication occur to facilitate the exchange of information between project investigators and staff internally, as well as disseminating the findings of the projects and cores and communicating research advances to the public. The management of this multi-million dollar proposal requires intensive administrative, fiscal and grants management expertise, of which the Administrative Core has nearly a decade of experience in providing to the current and previous COAST PPGs. The Administrative Core has five main objectives: (1) to provide grant administration and grant management services to the three projects and 2 other cores, (2) to aid communication between individual projects and cores, (3) to facilitate the review of scientific progress and communication of experimental results, (4) to coordinate student experiences, media requests, and collaborative project contacts and follow-up, and (5) to manage the interacting efforts of the individual projects such as subject recruitment and retention, tissue storage, and data use and storage. Responsibilities of the Administrative Core include: contacting COAST families to schedule visits/procedures and reserve clinic rooms, participant payments and retention, tracking biologic specimens and archiving them appropriately, and maintaining regulatory/IRB approval of COAST study materials and banked tissue samples. In order to fulfill these objectives and roles, the staff of the Administrative Core will include the Principal Investigator (Dr. Lemanske), the Laboratory Manager (Christopher Tisler), an Administrative Program Specialist/Human Subjects Coordinator (Elizabeth Anderson) and a research specialist (Theresa Kang). Departmental support is also provided by a program assistant (Susan Costello).

Public Health Relevance

RELEV/ NCE (See instructions): The Administrative Core provides the foundation to carry out the aims of this PPG and communicate its research advances to the public. Increasing public health awareness of COAST findings will be done through scientific publications, presentations, meetings, maintenance of the COAST website, and making banked tissue samples available to researchers to study areas beyond asthma.

National Institute of Health (NIH)
Research Program Projects (P01)
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Heart, Lung, and Blood Program Project Review Committee (HLBP)
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University of Wisconsin Madison
United States
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Nakagome, Kazuyuki; Bochkov, Yury A; Ashraf, Shamaila et al. (2014) Effects of rhinovirus species on viral replication and cytokine production. J Allergy Clin Immunol 134:332-41
Thomas, Amy O; Lemanske Jr, Robert F; Jackson, Daniel J (2014) Infections and their role in childhood asthma inception. Pediatr Allergy Immunol 25:122-8
Kloepfer, Kirsten M; Lee, Wai Ming; Pappas, Tressa E et al. (2014) Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations. J Allergy Clin Immunol 133:1301-7, 1307.e1-3
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Liggett, Stephen B; Bochkov, Yury A; Pappas, Tressa et al. (2014) Genome sequences of rhinovirus a isolates from wisconsin pediatric respiratory studies. Genome Announc 2:
Bousquet, Jean; Gern, James E; Martinez, Fernando D et al. (2014) Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop. J Allergy Clin Immunol 133:1535-46
Kruger, Stanley J; Fain, Sean B; Johnson, Kevin M et al. (2014) Oxygen-enhanced 3D radial ultrashort echo time magnetic resonance imaging in the healthy human lung. NMR Biomed 27:1535-41
Guilbert, Theresa W; Bacharier, Leonard B; Fitzpatrick, Anne M (2014) Severe asthma in children. J Allergy Clin Immunol Pract 2:489-500
Campbell, Catarina D; Mohajeri, Kiana; Malig, Maika et al. (2014) Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. PLoS One 9:e104396
Basta, Holly A; Ashraf, Shamaila; Sgro, Jean-Yves et al. (2014) Modeling of the human rhinovirus C capsid suggests possible causes for antiviral drug resistance. Virology 448:82-90

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