The Administrative Core provides the infrastructure and basic support for Projects I, II and III and Cores A and B to conduct their experiments and accomplish their research objectives. This core will serve as the common channel through which all scientific, administrative and fiscal communication occur to facilitate the exchange of information between project investigators and staff internally, as well as disseminating the findings of the projects and cores and communicating research advances to the public. The management of this multi-million dollar proposal requires intensive administrative, fiscal and grants management expertise, of which the Administrative Core has nearly a decade of experience in providing to the current and previous COAST PPGs. The Administrative Core has five main objectives: (1) to provide grant administration and grant management services to the three projects and 2 other cores, (2) to aid communication between individual projects and cores, (3) to facilitate the review of scientific progress and communication of experimental results, (4) to coordinate student experiences, media requests, and collaborative project contacts and follow-up, and (5) to manage the interacting efforts of the individual projects such as subject recruitment and retention, tissue storage, and data use and storage. Responsibilities of the Administrative Core include: contacting COAST families to schedule visits/procedures and reserve clinic rooms, participant payments and retention, tracking biologic specimens and archiving them appropriately, and maintaining regulatory/IRB approval of COAST study materials and banked tissue samples. In order to fulfill these objectives and roles, the staff of the Administrative Core will include the Principal Investigator (Dr. Lemanske), the Laboratory Manager (Christopher Tisler), an Administrative Program Specialist/Human Subjects Coordinator (Elizabeth Anderson) and a research specialist (Theresa Kang). Departmental support is also provided by a program assistant (Susan Costello).

Public Health Relevance

The Administrative Core provides the foundation to carry out the aims of this PPG and communicate its research advances to the public. Increasing public health awareness of COAST findings will be done through scientific publications, presentations, meetings, maintenance of the COAST website, and making banked tissue samples available to researchers to study areas beyond asthma.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL070831-12
Application #
8743246
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
City
Madison
State
WI
Country
United States
Zip Code
53715
Higano, Nara S; Hahn, Andrew D; Tkach, Jean A et al. (2016) Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magn Reson Med :
Anderson, Halie M; Lemanske Jr, Robert F; Arron, Joseph R et al. (2016) Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development. J Allergy Clin Immunol :
Rubner, Frederick J; Jackson, Daniel J; Evans, Michael D et al. (2016) Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence. J Allergy Clin Immunol :
Bochkov, Yury A; Watters, Kelly; Basnet, Sarmila et al. (2016) Mutations in VP1 and 3A proteins improve binding and replication of rhinovirus C15 in HeLa-E8 cells. Virology 499:350-360
Fawkner-Corbett, David W; Khoo, Siew Kim; Duarte, Carminha M et al. (2016) Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil. J Med Virol 88:58-63
Bochkov, Yury A; Gern, James E (2016) Rhinoviruses and Their Receptors: Implications for Allergic Disease. Curr Allergy Asthma Rep 16:30
Nicodemus-Johnson, Jessie; Myers, Rachel A; Sakabe, Noburu J et al. (2016) DNA methylation in lung cells is associated with asthma endotypes and genetic risk. JCI Insight 1:e90151
Anderson, Halie M; Lemanske Jr, Robert F; Evans, Michael D et al. (2016) Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk. J Allergy Clin Immunol :
Nicodemus-Johnson, Jessie; Naughton, Katherine A; Sudi, Jyotsna et al. (2016) Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. Am J Respir Crit Care Med 193:376-85
Bønnelykke, Klaus; Ober, Carole (2016) Leveraging gene-environment interactions and endotypes for asthma gene discovery. J Allergy Clin Immunol 137:667-79

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