The purpose of this Core is to provide for the administrative support for the Program Project and, thereby, this Core serves all four Projects and the other two Cores. This Core will provide the interface between the Program Project and the Lerner Research Institute and the Cleveland Clinic. In this capacity, the Core will help ensure that institutional compliance deadlines are met in a timely fashion, such as the filing human subject and animal research protocols. The Core will also provide the interface between the Program Project and NIH by seeing that Progress Reports and other correspondences are organized and submitted on time.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL073311-09
Application #
8378031
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
9
Fiscal Year
2012
Total Cost
$133,788
Indirect Cost
$100,483
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Biswas, Sudipta; Zimman, Alejandro; Gao, Detao et al. (2017) TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With Hyperlipidemia. Circ Res 121:951-962
Hirbawi, Jamila; Bialkowska, Katarzyna; Bledzka, Kamila M et al. (2017) The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation. J Biol Chem 292:14258-14269
Ithychanda, Sujay S; Dou, Kevin; Robertson, Stephen P et al. (2017) Structural and thermodynamic basis of a frontometaphyseal dysplasia mutation in filamin A. J Biol Chem 292:8390-8400
Feng, Weiyi; Valiyaveettil, Manojkumar; Dudiki, Tejasvi et al. (2017) ?3 phosphorylation of platelet ?IIb?3 is crucial for stability of arterial thrombus and microparticle formation in vivo. Thromb J 15:22
Zhu, Liang; Yang, Jun; Bromberger, Thomas et al. (2017) Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation. Nat Commun 8:1744
Wang, Yunmei; Gao, Huiyun; Shi, Can et al. (2017) Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIb?. Nat Commun 8:15559
Ding, Liang; Zhang, Lifang; Biswas, Sudipta et al. (2017) Akt3 inhibits adipogenesis and protects from diet-induced obesity via WNK1/SGK1 signaling JCI Insight 2:
Jawhara, Samir; Pluskota, Elzbieta; Cao, Wei et al. (2017) Distinct Effects of Integrins ?X?2 and ?M?2 on Leukocyte Subpopulations during Inflammation and Antimicrobial Responses. Infect Immun 85:
Sossey-Alaoui, Khalid; Pluskota, Elzbieta; Bialkowska, Katarzyna et al. (2017) Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration. Cancer Res 77:5129-5141
Ding, Liang; Zhang, Lifang; Kim, Michael et al. (2017) Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway. J Biol Chem 292:9283-9293

Showing the most recent 10 out of 97 publications