The Antigen Discovery Core will function to identify new PC antigens and enhance efficiency, quality control, and cooperation of research participants in their pursuit of program project objectives.
The Specific Aims of the Antigen Discovery Core will be: 1. To propagate Pneumocystis and maintain stocks of existing PC antigens. 2. To discover and characterize new PC antigens. 3. To perform antigen peptide T cell epitope analysis.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-PPG-A)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State Univ Hsc New Orleans
New Orleans
United States
Zip Code
Zheng, Mingquan; Cai, Yang; Eddens, Taylor et al. (2014) Novel pneumocystis antigen discovery using fungal surface proteomics. Infect Immun 82:2417-23
Chakraborty, Sourav; Cai, Yang; Tarr, Matthew A (2014) In vitro oxidative footprinting provides insight into apolipoprotein B-100 structure in low-density lipoprotein. Proteomics 14:2614-22
D'Souza, Alain J; Desai, Shyamal D; Rudner, Xiaowen L et al. (2013) Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. PLoS One 8:e56890
Kelly, Michelle N; Zheng, Mingquan; Ruan, Sanbao et al. (2013) Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina. J Immunol 190:285-95
Patil, Ujwal S; Qu, Haiou; Caruntu, Daniela et al. (2013) Labeling primary amine groups in peptides and proteins with N-hydroxysuccinimidyl ester modified Fe3O4@SiO2 nanoparticles containing cleavable disulfide-bond linkers. Bioconjug Chem 24:1562-9
Porretta, Elizabeth; Happel, Kyle I; Teng, Xu S et al. (2012) The impact of alcohol on BCG-induced immunity against Mycobacterium tuberculosis. Alcohol Clin Exp Res 36:310-7
Auten, Matthew W; Huang, Weitao; Dai, Guixiang et al. (2012) CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals. Vaccine 30:2768-77
Shi, Xin; Zhang, Ping; Sempowski, Gregory D et al. (2011) Thymopoietic and bone marrow response to murine Pneumocystis pneumonia. Infect Immun 79:2031-42
Siggins, Robert W; Melvan, John N; Welsh, David A et al. (2011) Alcohol suppresses the granulopoietic response to pulmonary Streptococcus pneumoniae infection with enhancement of STAT3 signaling. J Immunol 186:4306-13
Shi, Xin; LeCapitaine, Nicole J; Rudner, Xiaowen L et al. (2009) Lymphocyte apoptosis in murine Pneumocystis pneumonia. Respir Res 10:57

Showing the most recent 10 out of 22 publications