Program Plrector/Principal Investigator (Last, First, Middle): Burnett, John, C. Jr. PROJECT 2 Title: Novel Natriuretic Peptides and Delivery for Cardiorenal Disease. Project Descripfion: Advance the development of oral delivery in humans of the designer NP CD-NP and the development of a novel GC-A/-B acfivator tailored for cardiorenal disease. Project Leader: John C. Burnett, Jr.. MD;Professor of Medicine Other

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL076611-08
Application #
8495790
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
8
Fiscal Year
2013
Total Cost
$305,229
Indirect Cost
$111,701
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Huntley, Brenda K; Sandberg, Sharon M; Heublein, Denise M et al. (2015) Pro-B-type natriuretic peptide-1-108 processing and degradation in human heart failure. Circ Heart Fail 8:89-97
Mohammed, Selma F; Borlaug, Barry A; McNulty, Steven et al. (2014) Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail 7:580-9
Mohammed, Selma F; Mirzoyev, Sultan A; Edwards, William D et al. (2014) Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction. JACC Heart Fail 2:113-22
Wan, Siu-Hin; Vogel, Mark W; Chen, Horng H (2014) Pre-clinical diastolic dysfunction. J Am Coll Cardiol 63:407-16
Gladden, James D; Linke, Wolfgang A; Redfield, Margaret M (2014) Heart failure with preserved ejection fraction. Pflugers Arch 466:1037-53
Pereira, Naveen L; Redfield, Margaret M; Scott, Christopher et al. (2014) A functional genetic variant (N521D) in natriuretic peptide receptor 3 is associated with diastolic dysfunction: the prevalence of asymptomatic ventricular dysfunction study. PLoS One 9:e85708
Dandamudi, Sanjay; Slusser, Joshua; Mahoney, Douglas W et al. (2014) The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota. J Card Fail 20:304-9
Jain, Amit K; Chen, Horng H (2014) ROSE-AHF and lessons learned. Curr Heart Fail Rep 11:260-5
Mohammed, Selma F; Hussain, Imad; AbouEzzeddine, Omar F et al. (2014) Right ventricular function in heart failure with preserved ejection fraction: a community-based study. Circulation 130:2310-20
Ichiki, Tomoko; Schirger, John A; Huntley, Brenda K et al. (2014) Cardiac fibrosis in end-stage human heart failure and the cardiac natriuretic peptide guanylyl cyclase system: regulation and therapeutic implications. J Mol Cell Cardiol 75:199-205

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