Principal Investigator/Program Director (Last, First, Middle): KARLIN, ARTHUR CORE A. PROGRAM ADMINISTRATION Principal Investigator: Arthur Karlin Co-Investigator: Andrew Marks Core A. Program Administration Core leader: Arthur Karlin Co-Investigator: Andrew Marks The administration of the PPG will include the Principal Investigator (Arthur Karlin), the Co-Investigator (Andrew Marks), and the PPG administrator. This staff will be responsible for all activities related to administration of the PPG and its projects and cores. The overall responsibility for the PPG resides in the Principal Investigator and Director, Dr. Karlin. He will be responsible for the conduct and coordination of research and fiscal management at Columbia University. The Principal Investigators exercises his responsibility with the advice and assistance of the Executive Committee consisting of the Project Leaders for each project and each core. The Associate Director (Dr. Marks) will assist Dr. Karlin in the coordination of all PPG activities. Dr. Marks will oversee and coordinate the weekly PPG seminar series and will organize the annual Columbia University Symposium. The Administrative Core will maintain the Columbia University PPG Web

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL081172-04
Application #
8133508
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
4
Fiscal Year
2010
Total Cost
$77,124
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Zalk, Ran; Clarke, Oliver B; des Georges, Amédée et al. (2015) Structure of a mammalian ryanodine receptor. Nature 517:44-9
Marx, Steven O; Marks, Andrew R (2013) Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases. J Mol Cell Cardiol 58:225-31
Goldklang, Monica P; Perez-Zoghbi, Jose F; Trischler, Jordis et al. (2013) Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. FASEB J 27:4975-86
Wan, Elaine; Kushner, Jared S; Zakharov, Sergey et al. (2013) Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice. FASEB J 27:1859-67
Wu, Roland S; Liu, Guoxia; Zakharov, Sergey I et al. (2013) Positions of ?2 and ?3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel. J Gen Physiol 141:105-17
Niu, Xiaowei; Liu, Guoxia; Wu, Roland S et al. (2013) Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels. PLoS One 8:e58335
Morrow, John P; Katchman, Alexander; Son, Ni-Huiping et al. (2011) Mice with cardiac overexpression of peroxisome proliferator-activated receptor ? have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation 124:2812-21
Wu, Roland S; Marx, Steven O (2010) The BK potassium channel in the vascular smooth muscle and kidney: ýý- and ýý-subunits. Kidney Int 78:963-74
Liu, Guoxia; Niu, Xiaowei; Wu, Roland S et al. (2010) Location of modulatory beta subunits in BK potassium channels. J Gen Physiol 135:449-59
Kushnir, Alexander; Betzenhauser, Matthew J; Marks, Andrew R (2010) Ryanodine receptor studies using genetically engineered mice. FEBS Lett 584:1956-65

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