A.
Specific Aims The Administrative Core (AC) will provide support for planning, execution, and evaluation of the proposed research. The AC will support all administrative activities relating to the five projects and high throughput core enabling cohesion among the projects.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL081587-07
Application #
8376519
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
7
Fiscal Year
2012
Total Cost
$166,190
Indirect Cost
$59,904
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Farb, Melissa G; Park, Song-Young; Karki, Shakun et al. (2017) Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy. J Vis Exp :
Widlansky, Michael E; Puppala, Venkata K; Suboc, Tisha M et al. (2017) Impact of DPP-4 inhibition on acute and chronic endothelial function in humans with type 2 diabetes on background metformin therapy. Vasc Med 22:189-196
Brant, Luisa C C; Wang, Na; Ojeda, Francisco M et al. (2017) Relations of Metabolically Healthy and Unhealthy Obesity to Digital Vascular Function in Three Community-Based Cohorts: A Meta-Analysis. J Am Heart Assoc 6:
Karki, Shakun; Ngo, Doan T M; Farb, Melissa G et al. (2017) WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. Am J Physiol Heart Circ Physiol 313:H200-H206
Bretón-Romero, Rosa; Wang, Na; Palmisano, Joseph et al. (2016) Cross-Sectional Associations of Flow Reversal, Vascular Function, and Arterial Stiffness in the Framingham Heart Study. Arterioscler Thromb Vasc Biol 36:2452-2459
Farb, Melissa G; Karki, Shakun; Park, Song-Young et al. (2016) WNT5A-JNK regulation of vascular insulin resistance in human obesity. Vasc Med 21:489-496
Fuster, José J; Ouchi, Noriyuki; Gokce, Noyan et al. (2016) Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease. Circ Res 118:1786-807
Fetterman, Jessica L; Holbrook, Monica; Flint, Nir et al. (2016) Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis 247:207-17
Cooper, Leroy L; Palmisano, Joseph N; Benjamin, Emelia J et al. (2016) Microvascular Function Contributes to the Relation Between Aortic Stiffness and Cardiovascular Events: The Framingham Heart Study. Circ Cardiovasc Imaging 9:
Bretón-Romero, Rosa; Feng, Bihua; Holbrook, Monika et al. (2016) Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a-JNK Signaling. Arterioscler Thromb Vasc Biol 36:561-9

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