Development of congenic strains remains the most powerful tool to reduce an interval and demonstrate the mutation is present. For Project 1, we will reduce the interval from 13.2 Mb to <5Mb, and for Project 3 from 2.5 Mb to

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL082798-08
Application #
8486473
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$492,694
Indirect Cost
$170,671
Name
Medical College of Wisconsin
Department
Type
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Liu, Yong; Usa, Kristie; Wang, Feng et al. (2018) MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. J Am Soc Nephrol 29:2518-2528
Bukowy, John D; Dayton, Alex; Cloutier, Dustin et al. (2018) Do computers dream of electric glomeruli? Kidney Int 94:635
Liu, Pengyuan; Liu, Yong; Liu, Han et al. (2018) Role of DNA De Novo (De)Methylation in the Kidney in Salt-Induced Hypertension. Hypertension 72:1160-1171
Chuppa, Sandra; Liang, Mingyu; Liu, Pengyuan et al. (2018) MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Kidney Int 93:375-389
Widlansky, Michael E; Jensen, David M; Wang, Jingli et al. (2018) miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. EMBO Mol Med 10:
Kriegel, Alison J; Terhune, Scott S; Greene, Andrew S et al. (2018) Isomer-specific effect of microRNA miR-29b on nuclear morphology. J Biol Chem 293:14080-14088
Kumar, Vikash; Wollner, Clayton; Kurth, Theresa et al. (2017) Inhibition of Mammalian Target of Rapamycin Complex 1 Attenuates Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats. Hypertension 70:813-821
Hoffmann, Brian R; Stodola, Timothy J; Wagner, Jordan R et al. (2017) Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium. Arterioscler Thromb Vasc Biol 37:433-445
Mattson, David L; Liang, Mingyu (2017) Hypertension: From GWAS to functional genomics-based precision medicine. Nat Rev Nephrol 13:195-196
Dayton, Alex; Exner, Eric C; Bukowy, John D et al. (2016) Breaking the Cycle: Estrous Variation Does Not Require Increased Sample Size in the Study of Female Rats. Hypertension 68:1139-1144

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