The Administrative Core D will function as the central mechanism coordinating all of the administrative, research, and educational activities of the Program Project on Common Genetic Determinants of Asthma and COPD. In order to discharge this responsibility, the Core has three specific aims: (1) Provide administrative and logistical support for all four scientific projects and the cores of the PPG;(2) Record and monitor planning and progress, and coordinate all PPG research, educational, and dissemination activities, and coordinate communications between PPG investigators and the internal and external advisors;and (3) Coordinate and monitor all administrative activities between participating PPG institutions: Brigham and Women's Hospital, Jackson Laboratory, Harvard School of Public Health, and the NHLBI. The Core leader will be Dr. Scott T. Weiss, a senior research scientist and clinician with over 29 years of research administrative experience. Dr. Edwin Silverman will be the Co-Director. Dr. Weiss's Co- Investigators will include the other Principal Investigators from the Projects (Drs. Silverman, Paigen and Shapiro) and other Cores (Drs. Klanderman, Lange, and Lazarus) with whom Dr. Weiss has established longstanding, highly successful collaborations. The Administrative Core's work will ensure that the scientific work of the PPG can be conducted in a focused and efficient manner by facilitating effective communication among the institutions and investigators involved in the project, and between all of the investigators and both the Internal and External Advisory committees.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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Brigham and Women's Hospital
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McGeachie, Michael J (2017) Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease. Curr Opin Allergy Clin Immunol 17:104-109
Hobbs, Brian D; Parker, Margaret M; Chen, Han et al. (2016) Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 194:48-57
Hardin, M; Cho, M H; McDonald, M-L et al. (2016) A genome-wide analysis of the response to inhaled ?2-agonists in chronic obstructive pulmonary disease. Pharmacogenomics J 16:326-35
Kitsak, Maksim; Sharma, Amitabh; Menche, Jörg et al. (2016) Tissue Specificity of Human Disease Module. Sci Rep 6:35241
Ierodiakonou, Despo; Zanobetti, Antonella; Coull, Brent A et al. (2016) Ambient air pollution, lung function, and airway responsiveness in asthmatic children. J Allergy Clin Immunol 137:390-9
Howrylak, Judie A; Moll, Matthew; Weiss, Scott T et al. (2016) Gene expression profiling of asthma phenotypes demonstrates molecular signatures of atopy and asthma control. J Allergy Clin Immunol 137:1390-1397.e6
McGeachie, M J; Yates, K P; Zhou, X et al. (2016) Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med 374:1842-1852
McGeachie, Michael J; Yates, Katherine P; Zhou, Xiaobo et al. (2016) Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med 194:1465-1474
Zhou, Jin J; Cho, Michael H; Lange, Christoph et al. (2015) Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered 79:93-104
Sharma, Amitabh; Menche, Jörg; Huang, C Chris et al. (2015) A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Hum Mol Genet 24:3005-20

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