Principal Investigator/Program Director (Last, First, Middle): Romero, Juan C. COT6 B A. Core B: Imaging Core B. Core Director: Lilach O. Lerman, MD, PhD Co-Investigators: Erik L. Ritman, MD, PhD;James F. Glockner, MD, PhD;Sanjay Misra, MD. Administrator: James D. Krier, MS. C. DESCRIPTION OF CORE UNIT Core B will be responsible for whole-body tomographic imaging with a 64-slice multidetector helical CT (MDCT) and blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI), including data acquisition and image processing. Core B will involve coordination of all aspects of large animal MDCT (Projects 1 and 2) and BOLD (Project 1) imaging, and human MDCT and BOLD imaging (Project 4). The use of chronic experimental models, where timing of studies is coordinated with other procedures unique to each project, requires careful attention to scheduling and coordination between the Core B laboratory and the Project Investigators, Core B staff will be responsible for the design of imaging protocols,

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL085307-05
Application #
8299952
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2013-03-31
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$364,625
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Saad, Ahmed; Dietz, Allan B; Herrmann, Sandra M S et al. (2017) Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease. J Am Soc Nephrol 28:2777-2785
Wang, Wei; Saad, Ahmed; Herrmann, Sandra M et al. (2016) Changes in inflammatory biomarkers after renal revascularization in atherosclerotic renal artery stenosis. Nephrol Dial Transplant 31:1437-43
Kashyap, Sonu; Warner, Gina M; Hartono, Stella P et al. (2016) Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension. Am J Physiol Renal Physiol 310:F372-84
Kwon, Soon Hyo; Tang, Hui; Saad, Ahmed et al. (2016) Differential Expression of microRNAs in Urinary Extracellular Vesicles Obtained From Hypertensive Patients. Am J Kidney Dis 68:331-332
Saad, Ahmed; Zhu, Xiang-Yang; Herrmann, Sandra et al. (2016) Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia. Stem Cell Res Ther 7:128
Saad, Ahmed; Wang, Wei; Herrmann, Sandra M S et al. (2016) Atherosclerotic renal artery stenosis is associated with elevated cell cycle arrest markers related to reduced renal blood flow and postcontrast hypoxia. Nephrol Dial Transplant 31:1855-1863
Zhu, Xiang-Yang; Ebrahimi, Behzad; Eirin, Alfonso et al. (2015) Renal Vein Levels of MicroRNA-26a Are Lower in the Poststenotic Kidney. J Am Soc Nephrol 26:1378-88
Rhee, Eugene P; Clish, Clary B; Pierce, Kerry A et al. (2015) Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension. J Hypertens 33:836-42
Saad, Ahmed; Herrmann, Sandra M; Textor, Stephen C (2015) Chronic renal ischemia in humans: can cell therapy repair the kidney in occlusive renovascular disease? Physiology (Bethesda) 30:175-82
Widmer, R Jay; Flammer, Andreas J; Lerman, Lilach O et al. (2015) The Mediterranean diet, its components, and cardiovascular disease. Am J Med 128:229-38

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